Risk of stroke among patients with borderline personality disorder: A nationwide longitudinal study

Journal of Affective Disorders
Mu-Hong ChenKai-Lin Huang

Abstract

Previous studies suggested that patients with borderline personality disorder (BPD) had a higher prevalence of stroke-related risk factors, such as hypertension, dyslipidemia, and diabetes mellitus. But, the association between BPD and subsequent stroke has been rarely investigated. Using the Taiwan National Health Insurance Research Database, 5969 borderline patients aged 18 years and older and 23,876 age-and sex-matched controls were enrolled between 2002 and 2009, and followed up to the end of 2011 to identify the development of stroke. The Cox regression model after adjusting for demographic data, psychiatric comorbidities, and medical comorbidities showed that BPD was associated with an increased risk of developing any stroke (HR: 4.82, 95% CI: 2.77-8.40) and ischemic stroke (HR: 5.67, 95% CI: 2.49-12.93). The findings of sensitivity analysis after excluding the first year of observation were consistent: any stroke (HR: 3.44, 95% CI: 1.83-6.47) and ischemic stroke (HR: 4.75, 95% CI: 1.91-11.77). Patients with BPD had an elevated vulnerability to subsequent stroke and ischemic stroke compared to those without BPD. Further studies would be required to investigate the underlying mechanisms.

Citations

May 10, 2019·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·David J Castle
Jan 17, 2019·Journal of Personality Disorders·Paul A PilkonisNathan E Dodds
Aug 15, 2021·Journal of Neural Transmission·Juliane RauschKatja Bertsch

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