Risk of Stroke/Transient Ischemic Attack or Myocardial Infarction with Herpes Zoster: A Systematic Review and Meta-Analysis

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Yanting ZhangKe Li

Abstract

Accumulating evidence indicates that herpes zoster (HZ) may increase the risk of stroke/transient ischemic attack (TIA) or myocardial infarction (MI), but the results are inconsistent. We aim to explore the relationship between HZ and risk of stroke/TIA or MI and between herpes zoster ophthalmicus (HZO) and stroke. We estimated the relative risk (RR) and 95% confidence intervals (CIs) with the meta-analysis. Cochran's Q test and Higgins I2 statistic were used to check for heterogeneity. HZ infection was significantly associated with increased risk of stroke/TIA (RR = 1.30, 95% CI: 1.17-1.46) or MI (RR = 1.18, 95% CI: 1.07-1.30). The risk of stroke after HZO was 1.91 (95% CI 1.32-2.76), higher than that after HZ. Subgroup analyses revealed increased risk of ischemic stroke after HZ infection but not hemorrhagic stroke. The risk of stroke was increased more at 1 month after HZ infection than at 1-3 months, with a gradual reduced risk with time. The risk of stroke after HZ infection was greater with age less than 40 years than 40-59 years and more than 60 years. Risk of stroke with HZ infection was greater without treatment than with treatment and was greater in Asia than Europe and America but did not differ by sex. Our study ind...Continue Reading

Citations

Oct 3, 2018·Continuum : Lifelong Learning in Neurology·Kelly J Baldwin, Christopher L Cummings
Apr 12, 2019·Current Opinion in Infectious Diseases·Dinesh V Jillella, Dolora R Wisco
Sep 7, 2018·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Sachin KedarJoseph R Berger
Nov 22, 2018·PloS One·Harriet J ForbesCharlotte Warren-Gash
May 19, 2020·Human Vaccines & Immunotherapeutics·John LittAnthony L Cunningham
Mar 3, 2018·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Apr 25, 2019·Journal of Clinical Medicine·Ping-Hsun WuYi-Ting Lin
Apr 3, 2020·Infection·Pasquale PaglianoSilvano Esposito
May 29, 2018·Journal of Korean Medical Science·Young Soo Lee
Sep 25, 2018·The Journal of Infectious Diseases·Charlotte Warren-Gash
Apr 21, 2021·Stroke; a Journal of Cerebral Circulation·Quanhe YangRobert Merritt
Jun 4, 2021·Journal of the Neurological Sciences·Rajeev RanjanVivek Lal
Jul 29, 2021·NPJ Vaccines·Béatrice LaupèzeRobbert Van der Most
Jul 27, 2020·Journal of Vascular Surgery Cases and Innovative Techniques·Karan GargGlenn R Jacobowitz

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