Risk of subsequent cytological abnormality and cancer among women with a history of cervical intraepithelial neoplasia: a comparative study

Cancer Causes & Control : CCC
H MitchellJ B Carlin

Abstract

A longitudinal study of 1,281 women with a histological diagnosis of cervical intraepithelial neoplasia (CIN) during 1974-76 is presented. After 12 years of follow-up, 30 percent of the women had further cytological abnormalities reported. The rate of subsequent abnormality was highest during the first 12 months of follow-up; thereafter, there was no evidence of any decline in the rate of subsequent abnormality with increasing duration of follow-up. Women from the CIN cohort had twice as many later cytological abnormalities as an age-matched cohort of women who were negatively screened during 1974-76 (excluding abnormalities within 12 months of entry to the study and after adjustment for smear frequency). The CIN cohort remained at substantially greater risk for a subsequent diagnosis of squamous cell carcinoma of the cervix compared with the control group of negatively-screened women (rate ratio 19.8, 95 percent confidence interval 2.4-163.6, P less than 0.01). These results indicate that women who have received surgical intervention for CIN continue to have substantial morbidity from cervical abnormalities during medium-term follow-up.

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Citations

Jun 1, 1996·Australian and New Zealand Journal of Public Health·A M Kavanagh, J M Simpson
Nov 4, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kate CuschieriMarc Arbyn
Nov 15, 2005·International Journal of Cancer. Journal International Du Cancer·William Patrick SoutterTheo Panoskaltsis
Feb 1, 1994·Journal of the American College of Nutrition·A Nehlig, G Debry
Jan 1, 1996·Journal of Medical Screening·A M KavanaghH Mitchell

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