Risk of subsequent dementia among patients with bipolar disorder or major depression: a nationwide longitudinal study in Taiwan

Journal of the American Medical Directors Association
Mu-Hong ChenYa-Mei Bai

Abstract

Both major depression and bipolar disorder are associated with an increased risk of developing dementia. However, the differential risk of dementia between major depression and bipolar disorder is rarely investigated. Using the Taiwan National Health Insurance Research Database, a total of 2291 patients aged ≥ 55 years (major depression: 1946 and bipolar disorder: 345) and 2291 age-and sex-matched controls were enrolled between 1998 and 2008, and followed to the end of 2011. Participants who developed dementia during the follow-up were identified. Both patients with bipolar disorder [hazard ratio (HR) 5.58, 95% confidence interval (CI) 4.26-7.32] and those with major depression (HR 3.02, 95% CI 2.46-3.70) had an increased risk of developing dementia in later life, after adjusting for demographic data and medical comorbidities. The sensitivity tests after excluding the 1-year (bipolar disorder: HR 4.73, 95% CI 3.50-6.35; major depression: HR 2.62, 95% CI 2.11-3.25) and 3-year (HR 3.92, 95% CI 2.78-5.54; HR 2.21, 95% CI 1.73-2.83, respectively) follow-up duration also revealed consistent findings. Furthermore, patients with bipolar disorder were associated with an 87% increased risk (HR 1.87, 95% CI 1.48-2.37) of subsequent demen...Continue Reading

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Citations

May 3, 2015·Journal of the American Medical Directors Association·John E Morley
May 22, 2016·Journal of Affective Disorders·Pei-Shan TsaiMei-Yeh Wang
Oct 18, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Yi-An TuShih-Jen Tsai
Nov 7, 2015·Journal of the American Medical Directors Association·Barbara J Messinger-RapportJulie K Gammack
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Oct 10, 2020·Journal of Affective Disorders·Chang ChenYi-Ju Pan
Mar 6, 2021·Schizophrenia Research·Jingtao WangShuo Chen

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