Risk of suicide, deliberate self-harm and psychiatric illness after the loss of a close relative: A nationwide cohort study

World Psychiatry : Official Journal of the World Psychiatric Association (WPA)
Mai-Britt GuldinM Vestergaard

Abstract

The loss of a close relative is a common event, yet it is associated with increased risk of serious mental health conditions. No large-scale study has explored up to now the importance of the bereaved person's relation to the deceased while accounting for gender and age. We performed a nationwide Danish cohort study using register information from 1995 through 2013 on four sub-cohorts including all persons aged ≥18 years exposed to the loss of a child, spouse, sibling or parent. We identified 1,445,378 bereaved persons, and each was matched by gender, age and family composition to five non-bereaved persons. Cumulative incidence proportions were calculated to estimate absolute differences in suicide, deliberate self-harm and psychiatric illness. Cox proportional hazard regression was used to calculate hazard ratios while adjusting for potential confounders. Results revealed that the risk of suicide, deliberate self-harm and psychiatric illness was increased in the bereaved cohorts for at least 10 years after the loss, particularly during the first year. During that year, the risk difference was 18.9 events in 1,000 persons after loss of a child (95% CI: 17.6-20.1) and 16.0 events in 1,000 persons after loss of the spouse (95% CI...Continue Reading

References

Aug 1, 1967·Journal of Psychosomatic Research·T H Holmes, R H Rahe
Jun 15, 1995·American Journal of Epidemiology·C SchaeferS Wi
Jan 5, 2002·The Journal of Clinical Psychiatry·N M MelhemM K Shear
Dec 11, 2002·Social Science & Medicine·Orly Manor, Zvi Eisenbach
Mar 5, 2003·Journal of Anxiety Disorders·Stacey Kaltman, George A Bonanno
Aug 13, 2003·Archives of General Psychiatry·Ping Qin, Preben Bo Mortensen
May 21, 2004·Age and Ageing·Annette ErlangsenJames W Vaupel
Mar 25, 2005·The New England Journal of Medicine·Jiong LiPreben Bo Mortensen
May 26, 2005·Clinical Psychology Review·Wolfgang StroebeMargaret S Stroebe
Sep 29, 2005·The Journal of Clinical Psychiatry·Naomi M SimonM Katherine Shear
Feb 17, 2006·The New England Journal of Medicine·Nicholas A Christakis, Paul D Allison
Dec 11, 2007·Lancet·Margaret StroebeWolfgang Stroebe
May 31, 2008·American Journal of Public Health·Felix Elwert, Nicholas A Christakis
Jun 3, 2008·Journal of Health Economics·Javier Espinosa, William N Evans
Aug 5, 2009·PLoS Medicine·Holly G PrigersonPaul K Maciejewski
Jan 11, 2011·Journal of Affective Disorders·Anette KerstingBirgit Wagner
Aug 4, 2011·Scandinavian Journal of Public Health·Carsten Bøcker Pedersen
Aug 4, 2011·Scandinavian Journal of Public Health·Karin Helweg-Larsen
Aug 4, 2011·Scandinavian Journal of Public Health·Elsebeth LyngeMatejka Rebolj
Aug 4, 2011·Scandinavian Journal of Public Health·Helle Wallach KildemoesJesper Hallas
Oct 5, 2011·Archives of General Psychiatry·Merete NordentoftCarsten Bøcker Pedersen
Oct 8, 2013·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Andreas MaerckerGeoffrey M Reed
Dec 19, 2013·Trauma, Violence & Abuse·Mariëtte van DenderenPaul A Boelen
Sep 1, 2010·Death Studies·Elizabeth A LobbAnna Davies
Sep 14, 2014·Journal of Affective Disorders·Samuel ZetumerSidney Zisook
Jan 8, 2015·The New England Journal of Medicine·M Katherine Shear
Mar 12, 2015·Scandinavian Journal of Public Health·Annette Erlangsen, Izabela Fedyszyn
Apr 29, 2015·The Journal of Nervous and Mental Disease·Merete NordentoftIzabela Fedyszyn
Feb 3, 2016·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·James M BoltonJitender Sareen

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Citations

Jun 29, 2018·Depression and Anxiety·Jin-Young Min, Kyoung-Bok Min
Jan 25, 2020·International Journal of Environmental Research and Public Health·Lauren DrabwellAlexandra Pitman
Jun 15, 2020·European Journal of Public Health·Solveig Glestad ChristiansenLars Johan Hauge
Oct 18, 2019·Depression and Anxiety·Alana IglewiczSidney Zisook
May 17, 2019·Behavioral Sciences·Nicolette MolinaHolly G Prigerson
Mar 19, 2020·Social Psychiatry and Psychiatric Epidemiology·Katherine A OrnsteinLau C Thygesen
Jul 15, 2020·ELife·Huan SongUnnur A Valdimarsdóttir
Jul 20, 2020·Social Psychiatry and Psychiatric Epidemiology·Alexandra L PitmanDavid P J Osborn
Jun 12, 2020·BJGP Open·Mette Kjærgaard NielsenMai-Britt Guldin
Dec 29, 2020·Frontiers in Psychiatry·Mette Kjaergaard NielsenMai-Britt Guldin
Feb 11, 2020·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Franziska MeichsnerM Katherine Shear
Mar 4, 2021·BJGP Open·Caroline PearceStephen Barclay
Oct 26, 2021·Psychiatric Genetics·Oluwagbenga DadaVincenzo De Luca

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