Risk of transmission of human immunodeficiency virus infection during tympano-ossicular homograft: an experimental study

The Laryngoscope
P R MeylanP Monnier

Abstract

It is generally agreed that middle ear reconstructive surgery performed with tympano-ossicular homografts produces superior functional results compared with prosthetic material, especially with respect to extrusion rate. The use of homografts, though, has been seriously hampered recently by the fear of transmission of human immunodeficiency virus (HIV) infection. In HIV-infected patients, the virus is primarily found in the cells of the lymphoid and monocytic lineage. The nature of the tissues in the eardrum and ossicles, mostly fibrous tissue and compact bone without marrow, suggests that little virus load should be found in homografts. Indeed, culturing minced homograft tissue from two HIV-infected donors with acquired immune deficiency syndrome (AIDS) in a sensitive culture system with PHA-stimulated lymphoblasts produced no virus. Before use, homografts undergo a fixation procedure in 5% formaldehyde and then are kept in a solution containing Cialit as a preservative. The authors therefore examined the capacity of formaldehyde and Cialit to reduce the infectivity of HIV in models of infected tissue as measured in vitro. The reduction of in vitro infectivity due to these treatments was at least 10(5)-fold and 10(2)-fold, res...Continue Reading

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Citations

Oct 13, 2007·The Journal of Laryngology and Otology·D Lubbe, J J Fagan
Jan 23, 1999·The Laryngoscope·M A HotzR Häusler
Oct 4, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Vincent Van RompaeyPaul H Van de Heyning
Sep 14, 2007·Expert Review of Medical Devices·Olivier MalardPierre Corre
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Jul 24, 2007·Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris·O MalardA Saffarzadeh
Oct 3, 2008·Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris·F EspitalierP Bordure

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