Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population-based cohort study.

Annals of the Rheumatic Diseases
Rachel CharltonPROMPT study group

Abstract

To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. A cohort study using data from the UK Clinical Practice Research Datalink between 1998 and 2014. Patients with incident PsA aged 18-89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort. The incidence of uveitis, all IBD, Crohn's disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RRadj) were calculated using conditional Poisson regression. 6783 incident cases of PsA were identified with a median age of 49 years. The risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RRadj 3.55, 95% CI 2.21 to 5.70 and RRadj 2.13, 95% CI 1.40 to 3.24, respectively). A significant increase was observed for Crohn's disease (RRadj 2.96, 95% CI 1.46 to 6.00 and RRadj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RRadj1.30, 95% CI 0.66 to 2.56 and RRadj0.98, 95% CI 0.50 to 1.92). In a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn...Continue Reading

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Citations

Jun 19, 2019·The British Journal of Dermatology·A GreenUNKNOWN PROMPT study group
Sep 1, 2020·Journal of Cutaneous Medicine and Surgery·Megan LamRonald Vender
May 19, 2019·Rheumatology and Therapy·Jennifer Belasco, Nathan Wei
Dec 17, 2019·SAGE Open Medical Case Reports·Wasim HaidariSteven R Feldman
Apr 3, 2020·Rheumatology·Sizheng Steven ZhaoKarl Gaffney
Mar 9, 2021·Therapeutic Advances in Musculoskeletal Disease·Maria Sole ChimentiRoberto Perricone
Mar 22, 2021·Best Practice & Research. Clinical Rheumatology·Mitsumasa KishimotoShinya Kaname
Nov 17, 2020·The Journal of Rheumatology·Rachel A CharltonUNKNOWN PROMPT Study Group
May 22, 2021·Best Practice & Research. Clinical Rheumatology·Paras KarmacharyaAlexis Ogdie
Nov 20, 2021·Rheumatology and Therapy·Sneha Patel, Anand Kumthekar

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