Risk of venous thromboembolism in patients with splenic injury and splenectomy. A nationwide cohort study

Thrombosis and Haemostasis
Jiun-Nong LinC-H Kao

Abstract

The spleen is a crucial organ in humans. However, little is known about the association of venous thromboembolism (VTE) with splenic injury and splenectomy in trauma patients. The aim of this study was to determine the subsequent risk of VTE following splenic injury and splenectomy. A nationwide retrospective cohort study was conducted by analysing data from the National Health Insurance Research Database in Taiwan. We included 6,162 splenic injury patients (3,033 splenectomised and 3,129 nonsplenectomised patients) and 24,648 comparison patients who were selected by frequency match based on sex, age, and the index year during 2000-2006. All patients were followed until the occurrence of VTE, 31 December, 2011, death, or withdrawal from the insurance program. The age of patients with splenic injury was 41.93 ± 16.44 years. The incidence rates of VTE were 11.81, 8.46, and 5.21 per 10,000 person-years in the splenic injury patients with splenectomy, splenic injury patients without splenectomy, and comparison patients, respectively. Compared with the comparison cohort, splenic injury patients with splenectomy exhibited a 2.21-fold risk of VTE (95% confidence interval [CI], 1.43-3.43), whereas those without splenectomy exhibited a ...Continue Reading

References

Jul 1, 1978·Archives of Surgery·M A BoxerL Ellman
Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Nov 1, 1991·British Journal of Haematology·A W GoldfarbS Eisenberg
Dec 1, 1981·The British Journal of Surgery·A A DawsonA Munro
Apr 29, 1998·Acta Haematologica·C Borgna PignattiS Musumeci
Jun 1, 2000·The American Journal of Cardiology·A L KlatskyJ Poggi
Jan 19, 2002·The Journal of Infection·N BisharatR Raz
Dec 19, 2002·American Journal of Surgery·Emily R WinslowMary E Klingensmith
Jun 20, 2003·Circulation·Richard H White
Jun 20, 2003·Circulation·Frederick A Anderson, Frederick A Spencer
Sep 15, 2007·Pediatric Blood & Cancer·Sarah B TroendleGeorge R Buchanan
May 20, 2008·Journal of Thrombosis and Haemostasis : JTH·R F SchillingM I Traver
Jul 29, 2009·Blood·Shelley E Crary, George R Buchanan
Dec 31, 2010·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Rosario VecchioEva Intagliata
Feb 26, 2011·Pharmacoepidemiology and Drug Safety·Ching-Lan ChengMing Liang Lai
Apr 9, 2011·Lancet·Antonio Di SabatinoGino Roberto Corazza
Aug 8, 2012·The Journal of Trauma and Acute Care Surgery·David Zonies, Brian Eastridge
Apr 24, 2013·The Journal of Trauma and Acute Care Surgery·Scott C BrakenridgeUNKNOWN Inflammation and the Host Response to Injury Investigators
Jan 9, 2014·The Journal of Trauma and Acute Care Surgery·Robert M Van HarenKenneth G Proctor
Dec 3, 2014·American Journal of Surgery·Carl RosatiSteven C Stain
Dec 17, 2014·Journal of Neurosurgery·Kristopher T Kimmell, Babak S Jahromi
Dec 17, 2014·Injury·Martijn HommesAndrew John Nicol
Feb 6, 2015·Medicine·Hiroyuki TominagaSetsuro Komiya

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Citations

Jul 24, 2020·Blood·Rachael F Grace, Wilma Barcellini
Jan 27, 2019·British Journal of Haematology·Rachael F GraceWilma Barcellini
Jun 15, 2021·Pediatric Blood & Cancer·Satheesh ChonatRachael F Grace

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