Risk of virological failure in HIV-1-infected patients experiencing low-level viraemia under active antiretroviral therapy (ANRS C03 cohort study)

Antiviral Therapy
Marie-Anne VandenhendeAIDS Clinical Epidemiology Group of Aquitaine

Abstract

We assessed the association of persistent low-level viraemia between 50-199 copies/ml (LLV) with the risk of virological failure (VF) among HIV-1-infected patients receiving combination antiretroviral therapy (ART). ART-naive and ART-experienced patients followed up in the ANRS-CO3 Aquitaine Cohort were included if they started two nucleoside reverse transcriptase inhibitors (NRTIs) with either one non-nucleoside reverse transcriptase inhibitor (NNRTI) or one protease inhibitor boosted with ritonavir (PI/r) between 2000 and 2011 and achieved viral load (VL)<200 copies/ml 4-8 months after initiating ART. VF was defined as either two consecutive VL≥200 copies/ml or one VL≥200 followed by a modification of ART. LLV was defined as at least two consecutive VLs between 50-199 copies/ml for at least one month. We used Cox models to estimate the association of LLV with VF. Among 2,374 patients with a median follow-up of 3 years, 205 (8.6%) experienced LLV. LLV was strongly associated with further VF (adjusted hazard ratio [aHR] 2.30, 95% CI 1.65, 3.20). LLV was associated with VF in ART-experienced patients (aHR 3.02, 95% CI 2.10, 4.33) but not in ART-naive patients. Neither type of ART regimen (PI/r- versus NNRTI-based regimen) nor cu...Continue Reading

Citations

Oct 14, 2017·The Journal of Infectious Diseases·Helen M ChunDennis Ellenberger
Jun 27, 2017·AIDS·Jennifer S LeeUNKNOWN Center for AIDS Research Network of Integrated Clinical Systems
Jul 7, 2020·Journal of the International AIDS Society·Tavitiya SudjaritrukUNKNOWN TREAT Asia Pediatric HIV Observational Database of IeDEA Asia-Pacific
Feb 8, 2019·Infectious Diseases·Myriam den OudstenMarchina van der Ende
Feb 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christie JoyaAnuradha Ganesan

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