Risk of wound infection and safety profile of amoxicillin in healthy patients which required third molar surgery: a systematic review and meta-analysis

The British Journal of Oral & Maxillofacial Surgery
Mario Alberto Isiordia-EspinozaJ R Zapata-Morales

Abstract

The aim of this systematic review and meta-analysis was to assess the risk of surgical wound infection and the adverse effects of amoxicillin in healthy patients who required excision of third molars. We identified eligible reports from searches of PubMed, Medline®, the Cochrane Library, Imbiomed, LILACS, and Google Scholar. Studies that met our minimum requirements were evaluated using inclusion and exclusion criteria and the Oxford Quality Scale. Those with a score of 3 or more on this Scale were included and their data were extracted and analysed. For evaluation of the risk of infection the absolute risk reduction, number needed to treat, and 95% CI were calculated. For evaluation of the risk of an adverse effect the absolute risk increase, number needed to harm, and 95% CI were calculated using the Risk Reduction Calculator. Each meta-analysis was made with the help of the Mantel-Haenszel random effects model, and estimates of risk (OR) and 95% CI were calculated using the Review Manager 5.3, from the Cochrane Library. A significant risk was assumed when the lower limit of the 95% CI was greater than 1. Probabilities of less than 0.05 were accepted as significant. The results showed that there was no reduction in the risk o...Continue Reading

Associated Clinical Trials

Apr 27, 2017·Ana Kotarac Knežević

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May 29, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Othoniel H Aragon-MartinezSaray Aranda Romo
Aug 9, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Eva RamosIcíar Arteagoitia
Nov 20, 2016·Oral Diseases·P Holmstrup, B Klausen
Aug 14, 2020·Oral Diseases·Chiara CinquiniAntonio Barone
Apr 6, 2018·Journal of Maxillofacial and Oral Surgery·Mario Alberto Isiordia-EspinozaÁngel J Alonso-Castro
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Sep 12, 2020·Oral and Maxillofacial Surgery Clinics of North America·Patrick J Louis
May 22, 2021·The British Journal of Oral & Maxillofacial Surgery·T MilicD Gebauer
Jun 8, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Simra Azher, Amish Patel
Oct 16, 2020·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Joe IwanagaSoichiro Ibaragi

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