Risk Prediction Models for Acute Kidney Injury in Critically Ill Patients: Opus in Progressu

Nephron
Javier A Neyra, David E Leaf

Abstract

Acute kidney injury (AKI) is a complex systemic syndrome associated with high morbidity and mortality. Among critically ill patients admitted to intensive care units (ICUs), the incidence of AKI is as high as 50% and is associated with dismal outcomes. Thus, the development and validation of clinical risk prediction tools that accurately identify patients at high risk for AKI in the ICU is of paramount importance. We provide a comprehensive review of 3 clinical risk prediction tools that have been developed for incident AKI occurring in the first few hours or days following admission to the ICU. We found substantial heterogeneity among the clinical variables that were examined and included as significant predictors of AKI in the final models. The area under the receiver operating characteristic curves was ∼0.8 for all 3 models, indicating satisfactory model performance, though positive predictive values ranged from only 23 to 38%. Hence, further research is needed to develop more accurate and reproducible clinical risk prediction tools. Strategies for improved assessment of AKI susceptibility in the ICU include the incorporation of dynamic (time-varying) clinical parameters, as well as biomarker, functional, imaging, and genomi...Continue Reading

References

Mar 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sushrut S WaikarGlenn M Chertow
Dec 19, 2009·Journal of the American Society of Nephrology : JASN·Jean-Philippe Lafrance, Donald R Miller
Mar 25, 2011·Kidney International·Lakhmir S ChawlaCarlos E Palant
Nov 25, 2011·Kidney International·Steven G CocaChirag R Parikh
Apr 21, 2012·The American Journal of Medicine·Ron WaldUNKNOWN University of Toronto Acute Kidney Injury Research Group
Feb 8, 2013·Critical Care : the Official Journal of the Critical Care Forum·Kianoush KashaniJohn A Kellum
Feb 8, 2014·Journal of the American Society of Nephrology : JASN·Vin-Cent WuUNKNOWN NSARF Group
Jan 17, 2015·Nephron. Clinical Practice·Javier A NeyraUNKNOWN AKICI Study Group
Apr 13, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rakesh MalhotraRavindra Mehta
Nov 23, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nisha BansalEdward D Siew

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Citations

Feb 15, 2020·Acta Anaesthesiologica Scandinavica·Suvi T VaaraRinaldo Bellomo
Aug 5, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jennifer HolmesAled O Phillips
Oct 13, 2020·American Journal of Physiology. Renal Physiology·Y Diana KwongKathleen D Liu
Feb 11, 2021·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Ahmed Mohamed ZahranMohamed Esam Alebsawi
Mar 24, 2021·Critical Care Clinics·Javier A Neyra, Lakhmir S Chawla
Feb 20, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Victor Ortiz-SorianoJavier A Neyra
Apr 4, 2021·Seminars in Dialysis·Javier A Neyra, Kianoush Kashani

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