Risk profiles for heavy drinking in adolescence: differential effects of gender

Addiction Biology
Sambu SeoKlaus Obermayer

Abstract

Abnormalities across different domains of neuropsychological functioning may constitute a risk factor for heavy drinking during adolescence and for developing alcohol use disorders later in life. However, the exact nature of such multi-domain risk profiles is unclear, and it is further unclear whether these risk profiles differ between genders. We combined longitudinal and cross-sectional analyses on the large IMAGEN sample (N ≈ 1000) to predict heavy drinking at age 19 from gray matter volume as well as from psychosocial data at age 14 and 19-for males and females separately. Heavy drinking was associated with reduced gray matter volume in 19-year-olds' bilateral ACC, MPFC, thalamus, middle, medial and superior OFC as well as left amygdala and anterior insula and right inferior OFC. Notably, this lower gray matter volume associated with heavy drinking was stronger in females than in males. In both genders, we observed that impulsivity and facets of novelty seeking at the age of 14 and 19, as well as hopelessness at the age of 14, are risk factors for heavy drinking at the age of 19. Stressful life events with internal (but not external) locus of control were associated with heavy drinking only at age 19. Personality and stress...Continue Reading

References

Mar 29, 2002·European Psychiatry : the Journal of the Association of European Psychiatrists·A Heinz
Feb 28, 2003·Alcoholism, Clinical and Experimental Research·Edith V SullivanAdolf Pfefferbaum
Jun 21, 2003·Neural Computation·Sambu Seo, Klaus Obermayer
Nov 24, 2004·Neural Networks : the Official Journal of the International Neural Network Society·Sambu Seo, Klaus Obermayer
May 18, 2005·Alcoholism, Clinical and Experimental Research·K MannA Diehl
Jul 29, 2005·Journal of Studies on Alcohol·Michael WindleRebecca C Windle
Mar 15, 2006·Pharmacology, Biochemistry, and Behavior·J Nesic, T Duka
Sep 11, 2008·Journal of Studies on Alcohol and Drugs·Kevin M King, Laurie Chassin
Jul 14, 2009·Clinical Psychology Review·Marya T SchulteSandra A Brown
Sep 22, 2009·Brain and Cognition·Beatriz LunaKirsten O'Hearn
Jul 14, 2010·Journal of Behavioral Medicine·Monique MalmbergRutger C M E Engels
Aug 4, 2010·Biological Psychiatry·Karen D ErscheTrevor W Robbins
Nov 26, 2010·Molecular Psychiatry·G SchumannUNKNOWN IMAGEN consortium
Jan 26, 2011·The European Journal of Neuroscience·Simone Kühn, Jürgen Gallinat
Apr 20, 2011·Journal of Consulting and Clinical Psychology·Patricia J ConrodClare Mackie
Jun 3, 2011·Nature Reviews. Neuroscience·Adrienne J HeinzAndreas Heinz
Sep 29, 2011·Psychopharmacology·Lindsay M SquegliaSusan F Tapert
Feb 4, 2012·Science·Karen D ErscheEdward T Bullmore
Aug 21, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tobias Effertz, Karl Mann
Jul 31, 2013·Journal of Physiology, Paris·Morgana Croce da SilvaEster Miyuki Nakamura-Palacios
Nov 10, 2013·The American Journal of Drug and Alcohol Abuse·Monica LucianaKelvin O Lim
Nov 29, 2013·Addiction Biology·Rainer SpanagelEske M Derks
Dec 5, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Géraldine PetitSalvatore Campanella
Mar 19, 2014·Developmental Cognitive Neuroscience·Lindsay M SquegliaSusan F Tapert
Jun 26, 2014·Alcoholism, Clinical and Experimental Research·Yasmin MashhoonMarisa M Silveri
Jul 22, 2014·Nature·Robert WhelanUNKNOWN IMAGEN Consortium
May 20, 2015·The American Journal of Psychiatry·Lindsay M SquegliaAdolf Pfefferbaum
Jan 1, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Genane LoheswaranZafiris J Daskalakis

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Citations

Nov 13, 2019·Addiction Biology·Alexander GenauckNina Romanczuk-Seiferth
Jul 21, 2021·Biological Psychiatry·Emily L NewmanKlaus A Miczek

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