Risk score model for the development of hepatocellular carcinoma in treatment-naïve patients receiving oral antiviral treatment for chronic hepatitis B

Clinical and Molecular Hepatology
Won SohnYong-Han Paik

Abstract

This study aimed to develop and validate a risk prediction model for the development of hepatocellular carcinoma (HCC) in treatment-naïve patients receiving oral antiviral treatment for chronic hepatitis B (CHB). We investigated 2,061 Korean treatment-naïve patients with CHB treated with entecavir as an initial therapy. A risk score model for HCC development was developed based on multivariable Cox regression model in a single center (n=990) and was validated using the time-dependent area under the receiver operating characteristic curve (AUROC) in three other centers (n=1,071). The difference of HCC development among risk groups (low, intermediate, and high) categorized by risk score was also investigated. The cumulative incidence rates of HCC at 5 years were 11.2% and 8.9% in the testing and validation cohorts, respectively. HCC-Risk Estimating Score in CHB patients Under Entecavir (HCC-RESCUE) is formulated as (age+15×gender [female=0 / male=1]+23×cirrhosis [absence=0 / presence=1]). The AUROCs at 1 year, 3 years, and 5 years were 0.82, 0.81, and 0.81, respectively, in the validation cohort. A significant difference of HCC development in each risk group was determined by the 5-year HCC risk score in the validation cohort (lo...Continue Reading

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Citations

Dec 31, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Thodoris VoulgarisGeorge V Papatheodoridis
May 19, 2020·Antiviral Chemistry & Chemotherapy·Mohamed A Abd El AzizAntonio Facciorusso
Jul 1, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George V PapatheodoridisW Ray Kim
Jan 23, 2021·Journal of Clinical Medicine·Pierre NahonNathalie Ganne-Carrié
Oct 11, 2017·Journal of Hepatology·Naoto FujiwaraYujin Hoshida
May 28, 2021·JHEP Reports : Innovation in Hepatology·George V PapatheodoridisPietro Lampertico
May 19, 2021·World Journal of Clinical Cases·Jiang Guo, Xue-Song Gao
Aug 11, 2021·Viruses·Yashasavi SacharStephen E Congly

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Methods Mentioned

BETA
biopsy

Software Mentioned

R
RESCUE
HCC
SAS

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