Risk-specific follow-up for endometrial carcinoma patients

Gynecologic Oncology
A G ShumskyJ G Nation

Abstract

To propose a risk-specific follow-up protocol for endometrial carcinoma patients. A retrospective cohort of endometrial carcinoma patients was used to identify risk factors for recurrence. Based on a profile of risk factors, women were classified at either low or high risk for recurrence (median follow-up 70 months). The classification system was validated on a subsequent cohort. Surgical stage, grade, and histology were found to be significant predictors (P < 0.001) of recurrence. In the original cohort, patients with stage Ia, grade 1 or 2, or stage Ib, grade 1 adenocarcinoma, had a recurrence rate of 4/98 (4.1%). The remaining high-risk patients had a recurrence rate of 37/158 (23.4%). When applied to the subsequent cohort, the rates were similar: low risk 3/113 (2.7%) and high risk 30/140 (21.4%). Seventy-five percent of recurrences occurred within 3 years of diagnosis and the majority were heralded by site-specific symptoms. Women with endometrial carcinoma can be successfully classified for low or high risk of recurrence. It is proposed that low-risk patients not be maintained on routine follow-up and that a tailored schedule of follow-up be used for high-risk patients. These changes would serve patients more appropriatel...Continue Reading

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Citations

Sep 14, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·W A A TjalmaD J Cruickshank
Jul 9, 2010·Obstetrics and Gynecology International·Ying Zhang, Jian Wang
Jul 23, 2004·World Journal of Surgical Oncology·Karsten MünstedtHans-Rudolf Tinneberg
May 11, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F M KewD J Cruickshank
Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J R DijkstraM J E Mourits
Apr 27, 2010·Critical Reviews in Oncology/hematology·Angiolo Gadducci, Carlo Greco
Apr 25, 2006·Gynecologic Oncology·Himu LukkaJanice Kwon
Mar 25, 2006·Gynecologic Oncology·Michael Fung-Kee-FungUNKNOWN Cancer Care Ontario Program in Evidence-based Care Gynecology Cancer Disease Site Group
Feb 8, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F H van WijkC W Burger
Mar 18, 1999·Hematology/oncology Clinics of North America·R J Winn, N N Teng
Jun 1, 1997·Gynecologic Oncology·T W Burke
Jul 16, 2002·Radiologic Clinics of North America·Kazuro Sugimura, Hiromi Okizuka
Dec 27, 2005·Expert Review of Anticancer Therapy·Jonathan Carter, Selvan Pather
May 26, 2012·Archives of Gynecology and Obstetrics·Leszek GottwaldJanusz Piekarski

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