Risk stratification for central conventional chondrosarcoma of bone: A novel system predicting risk of metastasis and death in the Cancer Registry of Norway cohort

Journal of Surgical Oncology
Joachim ThorkildsenOlga Zaikova

Abstract

Interobserver variability in histological grading of central conventional chondrosarcoma (CCCS) limits the quality of patient information and research progression. We aim to quantify known and new prognostic variables and propose a risk stratification model. We selected 149 cases from the Cancer Registry of Norway. Cox proportional hazard models were estimated. Based on these results a dichotomous risk classification was proposed and presented by Kaplan-Meier estimates for rates of local recurrence, metastasis, and disease-specific survival. The influence of axial skeletal location (Hazard ratio [HR] = 19.06), a soft tissue component ≥1 cm (HR = 13.45), and histological grade 3 (HR = 16.46) are all significant in predicting the rate of metastasis. The creation of a variable combining axial skeletal location and a soft tissue component ≥1 cm strongly predicts the risk of metastasis (HR = 14.02; P < .001) and death (HR = 2.74; P = .030) at multivariate analysis, making the histological grade insignificant. Together with metastasis at diagnosis (HR = 285.65; P < .001), this forms the basis of our proposed risk stratification, producing a small high-risk group (39 cases with 33% risk of metastasis) and a large low-risk group (103 c...Continue Reading

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Citations

Aug 3, 2020·Clinical Orthopaedics and Related Research·Behrang Amini
Dec 15, 2020·Journal of Surgical Oncology·Joachim ThorkildsenOlga Zaikova
Oct 17, 2020·The Journal of Bone and Joint Surgery. American Volume·Peter S Rose
Jun 3, 2021·Cancers·Agnieszka E ZającPiotr Rutkowski

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