Risk Stratification for Ventricular Tachyarrhythmias by Ambulatory Electrocardiogram-Based Frequency Domain T-Wave Alternans

Pacing and Clinical Electrophysiology : PACE
Masato KawasakiMasatake Fukunami

Abstract

Ambulatory electrocardiogram (ECG)-based T-wave alternans (TWA) quantified by the modified moving average method (MMA) can be used to identify patients at risk for sudden cardiac death. However, there is no information available on ambulatory ECG-based TWA as quantified by the frequency domain (FD) method to identify patients with an implantable cardioverter defibrillator (ICD) who are at high risk for ventricular tachyarrhythmias. Further, there are few data regarding the comparison of clinical utility of FD-TWA with MMA-TWA, heart rate variability (HRV), and heart rate turbulence (HRT). In 41 patients with ICD, of whom 14 patients had a past history of at least one appropriate ICD discharge, FD-TWA, MMA-TWA, HRV, and HRT were analyzed from 24-hour Holter ECG monitoring recordings. Only positive results of FD-TWA and abnormal HRV (standard deviation of all normal-to-normal intervals ≤111 ms) were significantly more frequently observed in patients with than without appropriate ICD discharge. Patients with FD-TWA positive had a significantly higher risk of appropriate ICD discharge than those with FD-TWA negative (50% vs 16%; odds ratio, 5.3 [95% confidence interval, 1.2-23.7], P = 0.02). When FD-TWA and HRV were combined, the s...Continue Reading

References

Jan 27, 1994·The New England Journal of Medicine·D S RosenbaumR J Cohen
Jul 31, 1998·Journal of Cardiovascular Electrophysiology·N G KaveshM R Gold
Mar 17, 1999·Circulation·J M PastoreD S Rosenbaum
Jan 10, 2002·The American Journal of Cardiology·Takanori IkedaYukio Ozawa
Jan 18, 2002·Journal of Applied Physiology·Bruce D Nearing, Richard L Verrier
Feb 21, 2002·Circulation·Eric J RashbaMichael R Gold
Mar 22, 2002·The New England Journal of Medicine·Arthur J MossUNKNOWN Multicenter Automatic Defibrillator Implantation Trial II Investigators
May 28, 2002·Journal of Cardiovascular Electrophysiology·Daniel M BloomfieldRichard J Cohen
Jul 26, 2002·Journal of Cardiovascular Electrophysiology·Gioia TurittoNabil El-Sherif
Aug 22, 2003·Journal of Cardiovascular Electrophysiology·Richard L VerrierUNKNOWN ATRAMI Investigators
Jan 22, 2005·The New England Journal of Medicine·Gust H BardyUNKNOWN Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators
Jul 5, 2005·Journal of the American College of Cardiology·Anil K GehiJ Anthony Gomes
Jan 18, 2006·Journal of the American College of Cardiology·Sanjiv M Narayan
Jun 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira UenoTeruo Takano
Dec 6, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Takanori IkedaHideaki Yoshino
Dec 11, 2007·Journal of the American College of Cardiology·Derek V ExnerUNKNOWN REFINE Investigators
Nov 29, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Jin Won KimYoung-Hoon Kim
May 9, 2009·Pacing and Clinical Electrophysiology : PACE·Raja J Selvaraj, Vijay S Chauhan
Oct 20, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Shingo MaedaMitsuaki Isobe
Apr 14, 2010·Journal of Cardiovascular Electrophysiology·Paul S ChanBrahmajee K Nallamothu
Apr 3, 2013·JAMA Internal Medicine·Ryan T BorneFrederick A Masoudi

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Citations

Apr 21, 2018·Journal of Cardiovascular Electrophysiology·Serhat KocaOzcan Ozeke
Nov 8, 2018·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Kenichi HashimotoBonpei Takase
Jun 3, 2020·Physiological Measurement·Valeria BlesiusAndreas Dominik

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