Risk stratification in chronic lymphocytic leukemia

Seminars in Oncology
Till SeilerStephan Stilgenbauer

Abstract

Chronic lymphocytic leukemia (CLL) follows an extremely variable clinical course with survival ranging from months to decades. Available treatments can often induce remissions, but eventually all patients relapse. Recently, there has been major progress in the identification of molecular and cellular markers that may predict the tendency for disease progression in patients with CLL. Genomic aberrations, the mutational profile of IgVH genes and its surrogate marker ZAP-70 expression, and serum markers like B2-microglobulin (beta2-MG) and thymidine kinase (TK) provide prognostic information for individual patients independently of clinical disease characteristics. These molecular markers are about to enter the stage of risk stratification for individual patients in clinical trials.

References

Jan 1, 1989·Acta Haematologica·S Di GiovanniP Giallonardo
Feb 2, 1984·The New England Journal of Medicine·T HanA A Sandberg
Apr 8, 1999·Hematology and Cell Therapy·C MagnacK Maloum
Nov 7, 1999·The Journal of Biological Chemistry·L O BeitzA M Scharenberg
Jan 3, 2001·The New England Journal of Medicine·H DöhnerP Lichter
Aug 9, 2002·The New England Journal of Medicine·Stephan Stilgenbauer, Hartmut Döhner
May 2, 2003·The New England Journal of Medicine·Marta CrespoEmili Montserrat
Oct 15, 2003·Molecular & Cellular Proteomics : MCP·Duncan A E CochranAnthony D Whetton
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yuri VasconcelosGuillaume Dighiero
Jan 17, 2004·Lancet·Jenny A OrchardDavid G Oscier
Oct 2, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian HaslingerRoger Abseher
Mar 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J KeatingHagop Kantarjian
Apr 2, 2005·Blood·Pablo OppezzoUNKNOWN French Cooperative Group on CLL
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk L KienleStephan Stilgenbauer
Jan 19, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander KröberStephan Stilgenbauer

❮ Previous
Next ❯

Citations

Jan 27, 2009·Current Treatment Options in Oncology·Tahamtan AhmadiEdward Stadtmauer
Feb 1, 2007·Current Hematologic Malignancy Reports·Neil E Kay, Tait D Shanafelt
Dec 15, 2010·Current Hematologic Malignancy Reports·Xavier C BadouxWilliam G Wierda
Apr 22, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Llorenç Coll-Mulet, Joan Gil
May 22, 2013·International Journal of Hematology·Stefano BaldoniMauro Di Ianni
Nov 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mona LeuenbergerMarianne Tinguely
Dec 17, 2008·Hematology·John G Gribben
Nov 11, 2010·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Darko AntićIrena Djunić
Jan 5, 2011·International Journal of Hematology·Ludger SellmannAlexander Röth
Aug 3, 2013·Leukemia & Lymphoma·Tatjana Stankovic, Anna Skowronska
Jan 10, 2012·Leukemia & Lymphoma·Ludger SellmannRalf Küppers
Jul 14, 2010·Best Practice & Research. Clinical Haematology·Thorsten ZenzStephan Stilgenbauer
Jul 7, 2009·Hematology/oncology Clinics of North America·Dragan Jevremovic, David S Viswanatha
Aug 31, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Georgia MetzgerothJan Hastka
May 16, 2012·American Journal of Clinical Pathology·Khalil M CharafeddineRose T Daher
Oct 29, 2008·Hematology/oncology Clinics of North America·Stefan Peinert, John F Seymour
Aug 21, 2007·Best Practice & Research. Clinical Haematology·John G Gribben
Jun 4, 2008·Genes, Chromosomes & Cancer·Sonia FabrisAntonino Neri
May 22, 2008·British Journal of Haematology·Davide RossiGianluca Gaidano
Sep 4, 2010·British Journal of Haematology·Paolo SportolettiFranca Falzetti
Apr 8, 2011·Cytometry. Part B, Clinical Cytometry·Heba A DegheidyGerald E Marti
Jan 12, 2010·European Journal of Haematology·Zeynep A YeginMünci Yağci
May 2, 2008·Blood Reviews·Carol Moreno, Emili Montserrat
Oct 24, 2009·Blood·John G Gribben
May 3, 2007·Clinical Journal of Oncology Nursing·Kimberly Noonan
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan O'BrienKanti R Rai
Nov 25, 2006·Hematology·Emili Montserrat
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Birte FriedrichsMatthias Zeis
Jan 16, 2010·International Journal of Immunopathology and Pharmacology·L De MartinoV De Feo
Sep 4, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yen-Chun LiuJulia T Geyer
Nov 19, 2009·Cancer Research·Sandra LoederSimone Fulda

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.