Risk stratification in oral cavity squamous cell carcinoma by preoperative CRP and SCC antigen levels

Annals of Surgical Oncology
Shiang-Fu HuangHsuan-Ho Chen

Abstract

Squamous cell carcinoma antigen (SCC-Ag) level and C-reactive protein (CRP) have been shown to be associated with tumor invasion, lymph node metastasis, staging and survival in patients with oral squamous cell carcinoma (OSCC). The purpose of the present study was to analyze the relationship between preoperative levels of both SCC-Ag and CRP, with clinicopathologic factors and prognosis in OSCC patients. A retrospective study was performed on 142 OSCC patients between March 2008 and March 2011. Their serum SCC-Ag and CRP levels were measured preoperatively. SCC-Ag level of ≥2.0 ng/ml and CRP level ≥5.0 mg/L were significantly associated with pathologic tumor status (P < 0.001), pathologic nodal metastasis (P = 0.001), tumor depth (≥10 mm vs. <10 mm, P < 0.001), disease-free survival (P ≤ 0.001) and overall survival (P ≤ 0.001). The influence of SCC-Ag and CRP level on disease-free survival (hazard ratio 4.046, 95 % confidence interval 1.698-9.692) and overall survival (hazard ratio 3.655, 95 % confidence interval 1.464-9.130) still existed after adjusting for tumor status, lymph node metastasis and tumor cell differentiation. Concurrent high levels of both preoperative SCC-Ag and CRP levels act as a predictor for lymph node met...Continue Reading

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Citations

Jul 22, 2014·The Laryngoscope·Shiang-Fu HuangI-How Chen
Mar 17, 2016·Journal of Cancer Research and Clinical Oncology·Shin Hyuk YooSang Yoon Kim
Aug 22, 2015·World Journal of Surgical Oncology·Yin-Ping HsuShiang-Fu Huang
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Feb 15, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Hsueh WuYang-Che Wu
Jun 19, 2021·Journal of Dental Sciences·Yu-Hsueh WuChun-Pin Chiang

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