Risk stratification in patients with unstable angina and/or non-ST-elevation myocardial infarction by Troponin T and plasminogen-activator-inhibitor-1 (PAI-1)

Thrombosis Research
Andreja Sinkovic, Vojko Pogacar

Abstract

Increased Troponin T (TnT) and PAI-1 levels are markers of poor outcome in acute coronary syndromes (ACS). In order to stratify the risk for 30-day combined endpoint of mortality and/or reinfarction in unstable angina and/or non-ST-elevation myocardial infarction (UA/NSTEMI), TnT and PAI-1 levels were simultaneously assessed. The TnT and PAI-1 levels of 113 patients with UA/NSTEM were estimated within the first 48 h. Initial therapy was medical. Percutaneous coronary interventions were performed in case of recurrent ischemia and/or hemodynamic and/or rhythmic instability. Statistically significant differences in mean admission PAI-1 (4.2+/-3.4 vs. 2.8+/-2.4 U/ml, p<0.05), mean peak PAI-1 levels within the first 48 h (4.98 +/- 3.1 vs. 3.4 +/- 2.5 U/ml, p < 0.05), and no significant difference in any TnT level were observed between patients with and without 30-day mortality and/or reinfarction. The risk for 30-day mortality and/or reinfarction significantly increased in patients with admission PAI-1 levels > 4.0 U/ml (OR=4.44, 95%CI=1.47-13.4), peak PAI-1 levels > 4.0 U/ml (OR=5.78, 95%CI=1.838-18.20) and with simultaneously increased peak PAI-1 > 3.5 U/ml and TnT > 0.1 microg/l within the first 48 h (OR=4.9, 95%CI=1.569-15.385)....Continue Reading

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Citations

Aug 17, 2010·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Toshimitsu SatoKimihiro Komori
Oct 16, 2007·Diabetes Research and Clinical Practice·Yan Li CaoJin Zhang
Feb 27, 2007·Thrombosis Research·Chris CarlstenJeffrey H Sullivan
Jan 24, 2007·Journal of the American College of Cardiology·Saif AnwaruddinEric J Topol
Aug 1, 2008·Inhalation Toxicology·C CarlstenJ H Sullivan
Nov 26, 2009·The Journal of International Medical Research·M Marinsek, Andreja Sinkovic

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