Risk stratification of high-risk metastatic neuroblastoma: A report from the HR-NBL-1/SIOPEN study.

Pediatric Blood & Cancer
Daniel A MorgensternRuth Ladenstein

Abstract

Risk stratification is crucial to treatment decision-making in neuroblastoma. This study aimed to explore factors present at diagnosis affecting outcome in patients aged ≥18 months with metastatic neuroblastoma and to develop a simple risk score for prognostication. Data were derived from the European high-risk neuroblastoma 1 (HR-NBL1)/International Society for Paediatric Oncology European Neuroblastoma (SIOPEN) trial with analysis restricted to patients aged ≥18 months with metastatic disease and treated prior to the introduction of immunotherapy. Primary endpoint was 5-year event-free survival (EFS). Prognostic factors assessed were sex, age, tumour MYCN amplification (MNA) status, serum lactate dehydrogenase (LDH)/ferritin, primary tumour and metastatic sites. Factors significant in univariate analysis were incorporated into a multi-variable model and an additive scoring system developed based on estimated log-cumulative hazard ratios. The cohort included 1053 patients with median follow-up 5.5 years and EFS 27 ± 1%. In univariate analyses, age; serum LDH and ferritin; involvement of bone marrow, bone, liver or lung; and >1 metastatic system/compartment were associated with worse EFS. Tumour MNA was not associated with wors...Continue Reading

Associated Clinical Trials

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Citations

Feb 14, 2019·Children·Elizabeth Sokol, Ami V Desai
May 16, 2019·Open Biology·Ricky M TriggSuzanne D Turner
Oct 11, 2019·Journal of Pediatric Hematology/oncology·Anne L RyanMeredith S Irwin
Apr 10, 2020·Biomarkers in Medicine·Teresa Stachowicz-Stencel, Anna Synakiewicz
Nov 28, 2018·Pediatric Blood & Cancer·Daniel A MorgensternMeredith S Irwin
Aug 28, 2020·Pediatric Investigation·Hongjun FanXiaoli Ma
Jan 17, 2021·Vaccines·Fabio MorandiIrma Airoldi
Apr 1, 2021·Pediatric Blood & Cancer·Fumito YamazakiKimikazu Matsumoto
Jun 12, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Angela BelliniGudrun Schleiermacher
Jul 29, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Meredith S IrwinMichael D Hogarty
Aug 28, 2021·Journal of Personalized Medicine·Annabell SzymanskyJohannes H Schulte

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