Risk Stratification of Prostate Cancer Through Quantitative Assessment of PTEN Loss (qPTEN).

Journal of the National Cancer Institute
Tamara JamaspishviliDavid M Berman

Abstract

Phosphatase and tensin homolog (PTEN) loss has long been associated with adverse findings in early prostate cancer. Studies to date have yet to employ quantitative methods (qPTEN) for measuring of prognostically relevant amounts of PTEN loss in postsurgical settings and demonstrate its clinical application. PTEN protein levels were measured by immunohistochemistry in radical prostatectomy samples from training (n = 410) and validation (n = 272) cohorts. PTEN loss was quantified per cancer cell and per tissue microarray core. Thresholds for identifying clinically relevant PTEN loss were determined using log-rank statistics in the training cohort. Univariate (Kaplan-Meier) and multivariate (Cox proportional hazards) analyses on various subpopulations were performed to assess biochemical recurrence-free survival (BRFS) and were independently validated. All statistical tests were two-sided. PTEN loss in more than 65% cancer cells was most clinically relevant and had statistically significant association with reduced BRFS in training (hazard ratio [HR] = 2.48, 95% confidence interval [CI] = 1.59 to 3.87; P < .001) and validation cohorts (HR = 4.22, 95% CI = 2.01 to 8.83; P < .001). The qPTEN scoring method identified patients who re...Continue Reading

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Citations

Mar 5, 2020·Journal of the National Cancer Institute·Stephen M Hewitt
Sep 5, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stephanie A HarmonTamara Jamaspishvili
Oct 28, 2020·Cells·Daniel J TurnhamHelen B Pearson
May 30, 2021·Critical Reviews in Oncology/hematology·Dali Tong
Jun 28, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tim HansumGeert J L H van Leenders
Jul 21, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Debashis SarkerJohann S de Bono

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