Risk Stratification of Prostate Cancer Using the Combination of Histogram Analysis of Apparent Diffusion Coefficient Across Tumor Diffusion Volume and Clinical Information: A Pilot Study

Journal of Magnetic Resonance Imaging : JMRI
Zhao ZhangQiong Ye

Abstract

The effectiveness of quantitative MRI and clinical information in the risk stratification of prostate cancer (PCa) patients was evaluated separately in previous research; however, the differentiation power of combining quantitative MRI and clinical information has yet to be investigated. To investigate the power of combining histogram analysis of apparent diffusion coefficient (ADC) of tumor diffusion volume (tDv) with clinical information for the differentiation of low-grade (Gleason score [GS] ≤6) and high-grade (GS ≥7) PCa. Retrospective. Fifty-nine PCa patients who underwent preoperative diffusion-weighted imaging (DWI) (acquired with b = 0, 1000 mm2 /s) and followed by radical prostatectomy within 6 months. T2 -weighted, DWI, and ADC images at 3.0T. tDv defined with different ADC thresholds were analyzed for each patient and combined with age and prostate-specific antigen (PSA) level. Binary logistic regression with backward feature selection was applied to determine the best discrimination and corresponding combination of parameters. Kolmogorov-Smirnov test; independent samples t-test; Mann-Whitney U-test; Spearman's rank correlation; receiver operating characteristic (ROC) analysis; binary logistical regression. PSA and ...Continue Reading

References

May 1, 2008·Journal of Cancer Research and Clinical Oncology·Xiang-Yi ZhengZhao-Dian Chen
Aug 21, 2009·Investigative Radiology·Peter GibbsLindsay W Turnbull
Mar 31, 2012·Science Translational Medicine·John R PrensnerArul M Chinnaiyan
Nov 21, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Roger BourneGeoffrey Watson
Dec 19, 2013·The Journal of Urology·Daniel ReinhardtStacy Loeb
Nov 20, 2014·Journal of Magnetic Resonance Imaging : JMRI·Lars BoesenHenrik S Thomsen
Mar 19, 2015·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Daniel N CostaNeil M Rofsky
Apr 8, 2015·The Journal of Urology·Scott E EggenerWilliam T Lowrance
Jun 30, 2015·Journal of Magnetic Resonance Imaging : JMRI·Yu UedaKazuro Sugimura
Oct 3, 2015·European Urology·Jeffrey C WeinrebSadna Verma
Nov 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Duc FehrJoseph O Deasy
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Feb 26, 2016·Journal of Magnetic Resonance Imaging : JMRI·Thomas de PerrotJean-Paul Vallée
Jul 14, 2016·Journal of Magnetic Resonance Imaging : JMRI·Simpa S SalamiArdeshir R Rastinehad
Feb 7, 2018·Asian Journal of Andrology·Yi-Shuo WuQiang Ding

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.