Risk Stratification of Upper Urinary Tract Urothelial Carcinoma Patients for Survival Prediction: A Simple Summation Scoring Method

Journal of Cancer
Li-Jen WangYon-Cheong Wong

Abstract

Purpose: To stratify upper urinary tract urothelial carcinoma (UTUC) patients into risk groups in terms of 5-year survival. Methods and materials: All potential UTUC patients recorded in our cancer registry database from 1997 to 2011 were evaluated for authentic presence of UTUC. Age at diagnosis, sex, organ involvement, dialysis, renal transplantation status, clinical stage, survival to the last follow-up, and the cause of death of each patient were recorded. All patients were randomized into a developmental set or a validation set at a 1:1 ratio. Survival prediction models and scores were developed using the developmental set and validated in terms of discrimination and calibration using the validation set. Patients were stratified into risk groups using the summed risk scores and their survival compared by the log rank test. Results: We enrolled 1,120 authentic UTUC patients. In the developmental set, older age, male sex, and higher clinical staging were significant predictors of 5-year death after controlling for other variables. Based on these three clinical variables, patients were stratified into low-, intermediate-, high-, and very high-risk groups using the summed risk scores. The 5-year all-cause and cancer-specific s...Continue Reading

Citations

May 28, 2019·Expert Review of Anticancer Therapy·Mehdi Kardoust PariziShahrokh F Shariat
Feb 27, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Hao Lun LuoPo Hui Chiang
Nov 27, 2019·Expert Review of Anticancer Therapy·Jacob TaylorVitaly Margulis

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