Risk to all or none? A comparative analysis of controversies in the health risk assessment of Bisphenol A

Reproductive Toxicology
Anna BeroniusAnnika Hanberg

Abstract

Bisphenol A (BPA) is an endocrine disruptor for which health risk assessment has proven controversial. Conclusions regarding health risks of BPA vary between assessments from "there is no risk to any part of the population" to "there is risk to the entire population". We have carried out a literature study investigating what might be the scientific and/or policy-related reasons for these differences. Ten risk assessments for BPA were scrutinized and several factors were compared between assessments, including estimations of exposure levels, identification of critical study and NOAEL, assessment factors and significance attributed to reports of low-dose effects. Differences in conclusions were mainly influenced by the evaluation of low-dose effects and the uncertainties surrounding the significance of these data for health risk assessment. The results illustrate the impact of differences in risk assessment policy and expert judgment on the risk assessment process and highlight the importance of transparency in this process.

References

May 12, 2000·Proceedings of the Society for Experimental Biology and Medicine·C Gupta
Aug 15, 2001·Regulatory Toxicology and Pharmacology : RTP·C Rudén
Feb 7, 2002·Biochemical and Biophysical Research Communications·Toru Takeuchi, Osamu Tsutsumi
Apr 10, 2002·Environmental Health Perspectives·Ronald MelnickMichael Kohn
Jun 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·R W TylJ M Waechter
Jun 27, 2003·Environmental Health Perspectives·Wade V WelshonsFrederick S vom Saal
Oct 14, 2003·Journal of Toxicology and Environmental Health. Part a·Russell CarrScott Willard
Oct 30, 2004·Journal of Toxicology and Environmental Health. Part a·Beom Soo ShinSun Dong Yoo
Feb 25, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Michael D Shelby, UNKNOWN Center for the Evaluation of Risks to Human Reproduction Expert Panel
May 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Barry G TimmsFrederick S vom Saal
Jun 11, 2005·Human Reproduction·Mayumi Sugiura-OgasawaraKaoru Suzumori
Mar 17, 2006·Hormones and Behavior·Bryce C Ryan, John G Vandenbergh
Dec 13, 2006·Environmental Research·Audrey M CummingsRobert J Kavlock
Dec 15, 2006·Environmental Research·Agneta Falk-FilipssonMaria Wallén
Mar 21, 2007·Environmental Health Perspectives·Milena DurandoMónica Muñoz-de-Toro
Jul 3, 2007·Reproductive Toxicology·D Andrew CrainLouis J Guillette
Jul 14, 2007·Reproductive Toxicology·Yelena B WetherillScott M Belcher
Aug 9, 2007·Reproductive Toxicology·Catherine A RichterFrederick S vom Saal
Aug 21, 2007·Reproductive Toxicology·Ruth A KeriGail S Prins
Sep 11, 2007·Reproductive Toxicology·Laura N VandenbergWade V Welshons
Jan 17, 2008·Environmental Health Perspectives·Antonia M CalafatLarry L Needham
Jan 22, 2008·Toxicology and Applied Pharmacology·Wolfgang Dekant, Wolfgang Völkel
May 1, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rochelle W TylJohn M Waechter
Sep 19, 2008·JAMA : the Journal of the American Medical Association·Iain A LangDavid Melzer
May 30, 2009·Environmental Health Perspectives·Richard W StahlhutShanna H Swan
Jun 9, 2009·Regulatory Toxicology and Pharmacology : RTP·Anna BeroniusHelen Håkansson
Jun 9, 2009·Endocrine Reviews·Evanthia Diamanti-KandarakisAndrea C Gore

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Citations

Nov 29, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anne KatchyCecilia Williams
Dec 20, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Jinyan CaoHeather B Patisaul
May 7, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sherry A FergusonGrace E Kissling
Mar 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jinyan CaoHeather B Patisaul
Aug 5, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sherry A FergusonJordan S Abshire
Feb 16, 2013·Reproductive Toxicology·Laura N VandenbergR Thomas Zoeller
Jul 20, 2010·Frontiers in Neuroendocrinology·Andrea C Gore, Heather B Patisaul
Jul 26, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Meghan E RebuliHeather B Patisaul
Mar 20, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lina XingWeidong Hao
Sep 23, 2014·Current Opinion in Pharmacology·Anna BeroniusChristina Rudén
Nov 8, 2016·Environmental Science. Processes & Impacts·Ellen Ingre-KhansChristina Rudén
Dec 6, 2017·Environmental Science. Processes & Impacts·Marlene ÅgerstrandJulian Schenten
Aug 16, 2018·Risk Analysis : an Official Publication of the Society for Risk Analysis·Sander C S ClahsenErik Lebret
Dec 8, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Mari S GolubJames M Donald
Jan 11, 2019·Integrated Environmental Assessment and Management·Ellen Ingre-KhansChristina Rudén
Sep 25, 2015·Environmental Toxicology and Chemistry·Caroline T A MoermondMarlene Ågerstrand
Aug 9, 2019·European Journal of Oral Sciences·Trine L L BergeLars Björkman
Mar 16, 2012·Endocrine Reviews·Laura N VandenbergJohn Peterson Myers
Apr 30, 2017·Environmental Science. Processes & Impacts·Marlene ÅgerstrandChristina Rudén
Jul 5, 2017·Frontiers in Endocrinology·Heather B Patisaul
Aug 10, 2018·Toxicology Research·A Beronius, M Ågerstrand
May 8, 2019·Journal of Neuroendocrinology·Heather B Patisaul
Jan 1, 2014·Endocrine Disruptors·Cecilia WilliamsCory Teuscher
Feb 10, 2017·Clinical Oral Investigations·T L L BergeL Björkman
Aug 10, 2018·Toxicology Research·Michael ThoeneJoanna Wojtkiewicz
Jan 6, 2021·Environmental Science and Pollution Research International·Hamza KhallokZineb Hatim
Feb 12, 2021·Integrated Environmental Assessment and Management·Bronwyn McIlroy-YoungGunilla Öberg
Jan 12, 2021·Saudi Journal of Biological Sciences·Mohamed A Al-GriwAbdul Hakim Elnfati
Jun 6, 2020·The Science of the Total Environment·Jinwoo ImFelipe P J de Barros
Mar 18, 2015·The Science of the Total Environment·Benjamin LopezJean-Philippe Ghestem

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