Risk/benefit assessment in the treatment of Alzheimer's disease. Drug interactions

Revista española de geriatría y gerontología
María Jesús Hernández-Arroyo, Alfonso Díaz-Madero

Abstract

Anticholinergic drugs reduce the efficacy of acetylcholinesterase inhibitors (AChEI) and are inappropriate in elderly patients. The aim of this study is to determine the prevalence rate of prescription AChEI drugs and anticholinergics in a Healthcare Area, to identify the affected patients, and to inform the attending physicians, in order to evaluate the suitability of treatments. A descriptive cross-sectional observational study of prevalence. Patients on treatment with AChEI and any anticholinergic drug in the first quarter of 2015 were selected. The review of Duran et al. was used as reference to identify anticholinergics, assigning a score to each drug according to its anticholinergic potency. Physicians were provided with a report about the interaction, the list of affected patients, and recommendations. A total of 486 patients were included in the study, representing 59.0% of total patients with Alzheimer's disease in the Area. There were 66.0% women, and 86.8% of the patients were older than 75 years, and with a mean of 9.2 drugs per patient. The mean number of anticholinergic drugs was 1.6, and 38.3% of patients were prescribed various anticholinergic drugs, with 23.9% on high potency anticholinergic drugs. A statistica...Continue Reading

References

Jul 3, 2003·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ching-ju Lu, Larry E Tune
Dec 2, 2004·Journal of the American Geriatrics Society·Ryan M CarnahanElizabeth A Chrischilles
Jan 29, 2005·British Journal of Clinical Pharmacology·Nathalie Lechevallier-MichelAnnie Fourrier-Réglat
Dec 2, 2005·The New England Journal of Medicine·Philip S WangM Alan Brookhart
Aug 19, 2007·Journal of the American Geriatrics Society·Nathan HerrmannPaula A Rochon
Mar 12, 2008·Archives of Internal Medicine·James L RudolphRegina E McGlinchey
Apr 4, 2008·Journal of the American Geriatrics Society·Kaycee M SinkLaura P Sands
Aug 12, 2008·Journal of the American Geriatrics Society·Soko SetoguchiSebastian Schneeweiss
Jun 24, 2009·Pharmacoepidemiology and Drug Safety·M RobinsonV Mabbott
Aug 4, 2011·BMJ : British Medical Journal·Carol CouplandJulia Hippisley-Cox
Mar 2, 2012·Journal of the American Geriatrics Society·UNKNOWN American Geriatrics Society 2012 Beers Criteria Update Expert Panel
Mar 27, 2013·European Journal of Clinical Pharmacology·Carlos E DuránRobert H Vander Stichele
Oct 7, 2014·Journal of the American Geriatrics Society·Lisa M Kalisch EllettElizabeth E Roughead

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Citations

Jun 11, 2020·Expert Opinion on Drug Metabolism & Toxicology·Ramón Cacabelos

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