PMID: 11331438May 2, 2001Paper

Risk/benefit profile of arsenic trioxide

The Oncologist
D M Rust, S L Soignet

Abstract

Approximately 20%-30% of patients with acute promyelocytic leukemia (APL) who are treated with the current standard all-trans retinoic acid and anthracycline-based chemotherapy regimen suffer relapse. In the mid-1990s, studies from China reported the effective use of arsenic trioxide in achieving complete remission in patients with APL. In the United States, a multicenter trial of this agent in 40 patients with relapsed APL following conventional therapy confirmed the positive safety and efficacy outcomes of a smaller 12-patient pilot study. Common adverse events were hyperleukocytosis, APL differentiation syndrome, prolonged QT interval on electrocardiogram, skin rash, and hyperglycemia.

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Citations

Jul 14, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael F HughesDavid J Thomas
Dec 17, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zdenka ŠlejkovecIngrid Falnoga
May 19, 2009·Toxicology and Applied Pharmacology·Denise S HillRichard H Finnell
Feb 12, 2004·British Journal of Haematology·Dilip UnnikrishnanPeter H Wiernik
May 24, 2015·Cardiac Electrophysiology Clinics·Michael G Fradley, Javid Moslehi
Nov 19, 2002·Clinical Journal of Oncology Nursing·Jami MayorgaKarel A Dicke
May 12, 2005·Blood Reviews·Daniel V T Catenacci, Gary J Schiller
Nov 10, 2016·Environmental Toxicology and Pharmacology·Adeel SattarZonghui Yuan
Mar 3, 2011·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Jane E Rogers, Daisy Yang
Jan 1, 2014·3 Biotech·Mathews V VargheseR Harikumaran Nair
Mar 13, 2020·Metallomics : Integrated Biometal Science·Qian Qian WangHua Naranmandura
Aug 1, 2020·Expert Opinion on Investigational Drugs·Seokuee KimMyung-Ju Ahn
May 28, 2019·Current Treatment Options in Oncology·Sanjay Chandrasekhar, Michael G Fradley

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