PMID: 19132234Jan 10, 2009Paper

Risks and benefits of transcatheter thrombolytic therapy in patients with splanchnic venous thrombosis

Thrombosis and Haemostasis
Jasper H SmalbergFrank W G Leebeek

Abstract

Transcatheter local thrombolytic therapy in patients with acute, extended splanchnic venous thrombosis is controversial. Here we present our single-center experience with transcatheter thrombolytic therapy in these patients. All consecutive patients (n = 12) with acute, extended splanchnic venous thrombosis who underwent transcatheter thrombolytic therapy in our hospital, were included in this study. Thrombolytic therapy was successful for three thrombotic events and partially successful for four thrombotic events. Two patients developed minor procedure-related bleeding (17%). Six patients (50%) developed major procedure-related bleeding, with a fatal outcome in two. Transcatheter thrombolytic therapy in patients with acute, extended splanchnic vein thrombosis is found to be associated with a high rate of procedure-related bleeding. Therefore, thrombolysis should be reserved for patients in whom the venous flow cannot be restored by using conventional anticoagulant therapy or stent placement across the thrombosed vessel segment.

Citations

Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Lucio Amitrano, Maria Anna Guardascione
Jun 10, 2010·Internal and Emergency Medicine·Valerio De Stefano, Ida Martinelli
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Bashar HmoudPatrick S Kamath
Jan 5, 2016·Journal des maladies vasculaires·L Benjilali, L Essaadouni
Apr 27, 2012·Gastroenterología y hepatología·Susana SeijoJuan Carlos García-Pagán
Jun 28, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Harjit K Bhogal, Arun J Sanyal
Oct 12, 2010·Gastroentérologie Clinique Et Biologique·J DumortierF Pilleul
Oct 31, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
May 6, 2015·Journal of Clinical and Experimental Hepatology·Yogesh K Chawla, Vijay Bodh
Nov 9, 2015·Gastroenterología y hepatología·Elba Llop, Susana Seijo
Jan 19, 2016·Journal of Thrombosis and Thrombolysis·Walter AgenoMaurizio Paciaroni
Apr 2, 2014·Nature Reviews. Gastroenterology & Hepatology·Xingshun QiDaiming Fan
Jul 4, 2020·Journal of Thrombosis and Haemostasis : JTH·Marcello Di NisioWalter Ageno

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