Risks for cold frequency vary by sex: role of asthma, age, TLR7 and leukocyte subsets.

The European Respiratory Journal
Liisa M MurrayJohn W Upham

Abstract

Viral respiratory infections are usually benign but can trigger asthma exacerbations. The factors associated with upper respiratory tract infection (cold) frequency are not fully understood, nor is it clear whether such factors differ between women and men.To determine which immunological and clinical variables associate with the frequency of self-reported respiratory infections (colds), 150 asthma cases and 151 controls were recruited. Associations between antiviral immune response variables: toll-like receptor (TLR)7/8 gene expression, plasmacytoid dendritic cell (pDC) numbers and interferon-α, tumour necrosis factor and interleukin-12 production, and asthma were then examined that might explain cold frequency.People with asthma cases reported more colds per year (median 3 versus 2; p<0.001) and had lower baseline TLR7 gene expression (odds ratio 0.12; p=0.02) than controls. Associations between many variables and cold frequency differed between women and men. In women, high blood neutrophil counts (β=0.096, p=0.002), and younger age (β=-0.017, p<0.001), but not exposure to children, were independently associated with more frequent colds. In men, low TLR7 expression (β=-0.96, p=0.041) and high CLEC4C gene expression (a marker...Continue Reading

References

Jan 7, 2004·Australian and New Zealand Journal of Public Health·Karin LederAndrew Forbes
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beate BerghöferHolger Hackstein
Oct 17, 2006·The Journal of Biological Chemistry·Jianyong WangLaxma G Reddy
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Simon D MessageSebastian L Johnston
Sep 8, 2010·Lancet·William W BusseJames E Gern
Jan 5, 2011·Respiratory Research·Melanie L CarrollJohn W Upham
Dec 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hailing LuRobert M Hershberg
Dec 3, 2011·American Journal of Respiratory and Critical Care Medicine·E Kathryn MillerFernando P Polack
Feb 23, 2013·The European Respiratory Journal·Jason P LynchSimon Phipps
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Benoit DesnuesLena Alexopoulou
Feb 15, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nicholas A YoungWael N Jarjour
May 23, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X-Y ZhangP G Gibson
Aug 28, 2014·American Journal of Respiratory and Critical Care Medicine·Julie ChesnéAntoine Magnan
Mar 13, 2015·European Journal of Immunology·Adnan R KhanPadraic G Fallon
Dec 19, 2015·Clinical & Translational Immunology·Yang XiJohn W Upham
Aug 12, 2016·Pulmonary Therapy·Matea DeliuAdnan Custovic
Jun 28, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jian YeGuangyong Peng
Oct 11, 2017·The Journal of Allergy and Clinical Immunology·Michael R EdwardsSebastian L Johnston
Nov 22, 2017·Annals of the American Thoracic Society·Lisa G Wood
Jan 28, 2018·Science Immunology·Mélanie SouyrisJean-Charles Guéry
Feb 22, 2018·American Journal of Respiratory and Critical Care Medicine·Adnan CustovicSebastian L Johnston
Mar 9, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S KarkiB Liu
Mar 17, 2018·American Journal of Epidemiology·Alban RametteClaudia E Kuehni
Nov 6, 2018·Journal of Immunological Methods·Liisa MurrayJohn W Upham
Feb 13, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siew-Kim KhooAnthony Bosco

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