Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study

Medicine
Yi-Chun WangTe-Chao Fang

Abstract

Some statins (simvastatin, lovastatin, and atorvastatin) are metabolized by cytochrome P450s 3A4 (CYP3A4). Inhibitors of CYP3A4 including some calcium channel blockers (CCBs) might increase statin blood concentration, owing to drug-drug interactions. Risk of adverse events such as acute kidney injury might occur following the coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4.This was a population-based cohort study. The study analyzed data of patients treated between 1997 and 2011, retrieved from Taiwan's National Health Insurance database. We enrolled 32,801 patients who received coprescription of statins and CCBs that inhibit CYP3A4 (amlodipine, diltiazem, felodipine nicardipine, nifedipine, and verapamil). These patients were divided into 2 groups, according to whether they had received CYP3A4-metabolized statins (lovastatin, simvastatin, and atorvastatin) or non-CYP3A4-metabolized statins (fluvastatin, rosuvastatin, and pitavastatin). These 2 groups were 1:1 matched by age, gender, and Carlson comorbidity index. All outcomes were assessed within 90 days following drug coprescription.In this study, 5857 patients received coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. There ...Continue Reading

References

Nov 3, 1998·Clinical Pharmacology and Therapeutics·N E AzieS D Hall
Oct 26, 2001·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·H MarumoK Ichihara
Sep 24, 2002·The Annals of Pharmacotherapy·John J LewinMarian H Taylor
Apr 23, 2005·BMJ : British Medical Journal·Muhammad MamdaniGeoffrey M Anderson
Dec 21, 2006·Clinical Pharmacology and Therapeutics·Pertti J NeuvonenJanne T Backman
Aug 25, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hsuen-Fu LinTe-Chao Fang
Apr 27, 2012·International Journal of Clinical Pharmacy·Cristiano S MouraFrancisco A Acurcio
Jun 20, 2013·Annals of Internal Medicine·Amit M PatelAmit X Garg
Jul 3, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tsung-Hsing HungTe-Chao Fang
Dec 19, 2013·JAMA : the Journal of the American Medical Association·Sonja GandhiAmit X Garg
May 14, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mallika L Mendu, Sushrut S Waikar
Dec 24, 2014·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Daniel Q LiAmit X Garg
May 2, 2015·PloS One·Bo Ram YangByung-Joo Park
Aug 25, 2015·The Lancet. Diabetes & Endocrinology·Szu-Chun HungDer-Cherng Tarng

❮ Previous
Next ❯

Citations

Jul 9, 2016·The Annals of Pharmacotherapy·Ryan M RivosecchiSandra L Kane Gill
Jan 10, 2017·International Journal of Molecular Sciences·Elena ArrigoniAntonello Di Paolo
Sep 14, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Chu-Lin ChouTe-Chao Fang
Jul 10, 2018·Current Vascular Pharmacology·Gabriella RicciFrancesca Cortese
Jun 13, 2019·Pharmaceutical Biology·Yan RenXing Liu
Aug 18, 2017·Drugs & Aging·Sana KhanMitchell H Rosner
Jun 21, 2017·Case Reports in Critical Care·Iouri BanakhRavindranath Tiruvoipati
Mar 25, 2021·Expert Opinion on Drug Metabolism & Toxicology·Luis Fernando Valladales-RestrepoJorge Enrique Machado-Alba
Mar 26, 2021·Cell Reports Medicine·Polina MamoshinaAlfonso Bueno-Orovio
Mar 9, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chang LiuYun Sun

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.