Risks of diuretic usage following stroke

Neurorehabilitation and Neural Repair
Matthew ChurchillMichael Reding

Abstract

To assess the effects of diuretic use on hydration status following stroke. Admission serum hydration markers and neurologic assessments were prospectively recorded for 296 stroke rehabilitation inpatients with stable renal function. Dysphagia was defined by bedside dysphagia evaluation and subsequent modified barium swallow, if necessary. Serum hydration markers were checked at approximate 10-day intervals. Analysis of variance was used to test the effects of clinical variables on serum markers for hydration during the rehabilitation hospital stay. Odds ratios were used to quantify the risks of developing a blood urea nitrogen value > or = 45 mg/dl. The mean peak blood urea nitrogen associated with each of the following were diuretic usage yes/no (33 mg/dl +/- 18/26 +/- 17, P < 0.01), dysphagia yes/no (32 +/- 21/25 +/- 14, P < 0.001), and need for thin-liquid restriction yes/no (34 +/- 20/25 +/- 15, P < 0.001). The odds ratio for developing a peak blood urea nitrogen > or = 45 for patients taking a diuretic with evidence of penetration or aspiration documented by modified barium swallow was (19.8, P < 0.001). The odds ratio for developing a peak blood urea nitrogen > or = 45 for those taking a diuretic who needed thin-liquid r...Continue Reading

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Citations

Feb 10, 2010·Spinal Cord·P SekaranR K Senthil Kumar
Sep 10, 2010·The American Journal of Emergency Medicine·Leng C LinW C Fann
Dec 20, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Fang WangJing-Yan Han
Dec 14, 2011·Stroke; a Journal of Cerebral Circulation·Anne RowatMartin Dennis
Sep 1, 2018·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·Holly GoroffMichael Reding

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