PMID: 12786799Jun 6, 2003Paper

Risks of mortality in children admitted to the paediatric intensive care unit after haematopoietic stem cell transplantation

British Journal of Haematology
Maren TomaskeD Niethammer

Abstract

The risk of mortality in children admitted to the paediatric intensive care unit (PICU) after haematopoietic stem cell transplantation is felt to be very high. Life-threatening complications leading to PICU admission are due to organ toxicity caused by conditioning regimes and graft-versus-host disease (GVHD), systemic infections and other organ dysfunctions. Data collected between October 1998 and December 2001 of paediatric patients undergoing haematopoietic stem cell transplantation and thereafter admitted to the PICU were retrospectively analysed in order to reveal the possible causes and risk factors related to death while in the PICU. Twenty-six PICU admissions were recorded. We found a mortality rate of 57.7% and a 6-month survival rate of 23.1%. Univariate analysis identified an oncological paediatric risk of mortality (O-PRISM) score above 10 points, sustained renal failure and a failed negative fluid balance as significant predictors to non-survival.

References

Jan 1, 1989·Critical Care Medicine·S J DenardoP E Bellamy
Sep 1, 1994·Critical Care Medicine·D G NicholsM C Rogers
May 1, 1996·Critical Care Medicine·M M PollackU E Ruttimann
Mar 1, 1996·Intensive Care Medicine·A van VeenE van der Voort

❮ Previous
Next ❯

Citations

Apr 20, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lorenz GrigullHans-Gert Heuft
Jun 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tonya S Rans, Ronald England
Jul 9, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Carol E Nicholson
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert Tamburro
Jul 14, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ranjit S ChimaSonata Jodele
Feb 9, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christine N DuncanUNKNOWN Pediatric Acute Lung Injury and Sepsis (PALISI) Network
Jul 23, 2013·Hämostaseologie·V WiegeringP G Schlegel
Feb 3, 2009·Clinics in Chest Medicine·John R McArdle
Nov 25, 2005·Pediatric Transplantation·Kevin J SullivanMichael Joyce
Sep 27, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lama ElbahlawanR Ray Morrison
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Javier Chinen, Jennifer M Puck
Jan 4, 2017·Journal of Korean Medical Science·Ok Jeong LeeJoongbum Cho
Dec 28, 2018·Journal of Educational Evaluation for Health Professions·Nila S RadhakrishnanZareen Zaidi
Jan 25, 2007·Annals of Surgery·Donald W Moorman
May 28, 2010·Academic Medicine : Journal of the Association of American Medical Colleges·Iris WallenburgPauline Meurs
Dec 27, 2005·Academic Medicine : Journal of the Association of American Medical Colleges·James E CoverdillAlexandra L B Webb
Sep 3, 2010·Current Opinion in Critical Care·Mary Dixon-Woods, Charles Bosk
Aug 1, 2008·Academic Medicine : Journal of the Association of American Medical Colleges·Judah L Goldberg
Jun 13, 2019·Journal of Intensive Care Medicine·Dana M MuellerRobinder G Khemani
Jun 11, 2020·Pediatric Blood & Cancer·Diana A SteppanUNKNOWN Pediatric ECMO (PediECMO) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Extr
Dec 15, 2020·Pediatric Transplantation·Marie Louise Naestholt JensenMarianne Ifversen
Oct 14, 2020·The American Journal of Emergency Medicine·Imad El MajzoubJean El Cheikh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.