Risks of selected congenital malformations among offspring of mixed race-ethnicity

Birth Defects Research. Part A, Clinical and Molecular Teratology
Juan YangGary M Shaw

Abstract

Little is known about the occurrence of specific congenital malformations among offspring of mixed race-ethnicity. Using data from a population-based registry, we explored the occurrence of selected malformation phenotypes in offspring to parents who were of different race-ethnicity. Data were derived from the California Birth Defects Monitoring Program, a population-based active surveillance system for collecting information on infants and fetuses with congenital malformations using multiple source ascertainment. Approximately 2.6 million live births and stillbirths occurred during 1989-2000. Information on parental race-ethnicity (non-Hispanic white, Hispanic, black, and Asian) was obtained from birth certificates and fetal death files. Malformation phenotypes studied were spina bifida, anencephaly, cleft lip, cleft palate, tetralogy of Fallot, d-transposition of great arteries, hypospadias, small intestinal atresia, preaxial polydactyly, microtia, and hypertrophic pyloric stenosis. A total of 11.2% of births were to parents of mixed race-ethnicity. Compared to births of parents who were both white, moderately increased risks (risk ratio >/= 1.7) of anencephaly, polydactyly, and microtia, and decreased risks (risk ratio </= 0...Continue Reading

References

Oct 1, 1991·Paediatric and Perinatal Epidemiology·L A CroenJ A Harris
Aug 1, 1993·American Journal of Public Health·J W Collins, R J David
Jul 1, 1995·Teratology·J HarrisE Robert
Jan 1, 1996·International Journal of Health Services : Planning, Administration, Evaluation·D R Williams
Oct 1, 1996·Journal of Medical Genetics·J HarrisE Robert
Sep 17, 1998·American Journal of Medical Genetics·L A CroenM M Tolarová
Nov 15, 2000·American Journal of Public Health·E J SondikS S Smith
Mar 7, 2001·Pediatrics·L D BottoJ D Erickson
Nov 28, 2002·American Journal of Public Health·Jennifer D Parker, Jennifer H Madans

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Citations

Mar 1, 2012·Human Reproduction Update·L F M van der ZandenN Roeleveld
Dec 30, 2014·Pediatrics and Neonatology·Alexander C Egbe
May 17, 2005·Prenatal Diagnosis
Nov 23, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Daniela V LuquettiEduardo E Castilla
Jun 10, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Daniela Varela LuquettiPierpaolo Mastroiacovo
Nov 23, 2011·American Journal of Medical Genetics. Part a·Daniela V LuquettiTimothy C Cox
Jul 31, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Adrienne T HoytUNKNOWN National Birth Defects Prevention Study
Jun 10, 2008·American Journal of Obstetrics and Gynecology·Hyagriv N Simhan, Marijane A Krohn
Oct 13, 2017·Journal of Community Genetics·Sowmiya MoorthieUNKNOWN Congenital Disorders Expert Group
Jan 10, 2019·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Daniela V LuquettiCarrie L Heike
May 20, 2014·Journal of Perinatal Medicine·Alexander EgbeShubhika Srivastava
Apr 1, 2019·International Journal of Pediatric Otorhinolaryngology·Marisa A RyanUNKNOWN National Birth Defects Prevention Study

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