Risky business: Microhomology-mediated end joining

Mutation Research
Supriya SinhaSang Eun Lee

Abstract

Prevalence of microhomology (MH) at the breakpoint junctions in somatic and germ-line chromosomal rearrangements and in the programmed immune receptor rearrangements from cells deficient in classical end joining reveals an enigmatic process called MH-mediated end joining (MMEJ). MMEJ repairs DNA double strand breaks (DSBs) by annealing flanking MH and deleting genetic information at the repair junctions from yeast to humans. Being genetically distinct from canonical DNA DSB pathways, MMEJ is involved with the fusions of eroded/uncapped telomeres as well as with the assembly of chromosome fragments in chromothripsis. In this review article, we will discuss an up-to-date model representing the MMEJ process and the mechanism by which cells regulate MMEJ to limit repair-associated mutagenesis. We will also describe the possible therapeutic gains resulting from the inhibition of MMEJ in recombination deficient cancers. Lastly, we will embark on two contentious issues associated with MMEJ such as the significance of MH at the repair junction to be the hallmark of MMEJ and the relationship of MMEJ to other mechanistically related DSB repair pathways.

References

Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·F LiangM Jasin
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·J E Haber, W Y Leung
Nov 29, 2002·Microbiology and Molecular Biology Reviews : MMBR·Lorraine S Symington
Dec 25, 2007·Cell Research·Meena ShrivastavJac A Nickoloff
Jun 11, 2008·Molecular and Cellular Biology·Anwaar AhmadLaura J Niedernhofer
Apr 15, 2009·The Journal of Experimental Medicine·Isabelle RobertBernardo Reina-San-Martin
Jul 15, 2009·Nature Reviews. Genetics·P J HastingsGrzegorz Ira
Jul 28, 2009·Nature Structural & Molecular Biology·Anyong XieRalph Scully
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cristian BoboilaFrederick W Alt
Apr 7, 2010·Nature Genetics·Donald F ConradMatthew E Hurles
Dec 7, 2010·Nature Structural & Molecular Biology·Yu Zhang, Maria Jasin
Dec 7, 2010·Nature Structural & Molecular Biology·Mieun Lee-TheilenJayanta Chaudhuri
Aug 2, 2011·Seminars in Cell & Developmental Biology·Rita ColnaghiMark O'Driscoll
Sep 14, 2011·Annual Review of Genetics·Lorraine S Symington, Jean Gautier
Nov 25, 2011·Molecular Cancer Research : MCR·Lisa A TobinFeyruz V Rassool
Dec 27, 2011·Mutation Research·Yanguo LiuLi Liang
May 1, 2012·The Journal of Biological Chemistry·Hailong WangXiaohua Wu
Nov 13, 2012·PLoS Genetics·Diana D VillarrealSang Eun Lee
Jan 12, 2013·Science·Michal ZimmermannTitia de Lange
Apr 9, 2013·Frontiers in Genetics·Anabelle Decottignies
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lan N TruongXiaohua Wu

❮ Previous
Next ❯

Citations

Jun 25, 2016·International Journal of Molecular Sciences·Benoît RanchouxSébastien Bonnet
Sep 14, 2016·Progress in Retinal and Eye Research·Mert YanikKnut Stieger
Feb 1, 2017·Radiation Research·Howard B LiebermanConstantinos G Broustas
Apr 11, 2017·Viruses·Thomas TuStephan Urban
May 5, 2017·Cells·Nadine Nilles, Birthe Fahrenkrog
Nov 10, 2017·Nucleic Acids Research·Varandt Y KhodaverdianMitch McVey
Nov 6, 2018·Human Genetics·Svetlana A SmirnikhinaAlexander V Lavrov
Oct 13, 2016·Annual Review of Genetics·James E Haber
Dec 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sébastien LeclercqRichard Cordaux
May 11, 2019·Scientific Reports·Hiroyuki YamazakiAkifumi Takaori-Kondo
Jul 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Denis A KiktevThomas D Petes
Jan 20, 2017·Cell & Bioscience·Hailong Wang, Xingzhi Xu
Dec 2, 2020·Open Biology·Patricia Pérez-ArnaizThorsten Allers
Apr 1, 2021·Trends in Genetics : TIG·Dipayan Ghosh, Sathees C Raghavan
May 4, 2021·Frontiers in Genetics·Tímea PóczaAnikó Bozsik
Jun 19, 2021·Proceedings of the National Academy of Sciences of the United States of America·Xuejie WangXuefeng Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Control & Proteolysis

Key regulators of cell cycle, including cyclins, cyclin dependent kinase inhibitors, DNA replication factors, are controlled by proteolysis. Discover the latest research on cell cycle control and proteolysis.