Risperidone and falls in ambulatory nursing home residents with dementia and psychosis or agitation: secondary analysis of a double-blind, placebo-controlled trial

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
I R KatzLon Schneider

Abstract

Authors evaluated the association between use/dosage of risperidone (RIS) and falls in a residential-care dementia population. Authors performed secondary analysis of data from ambulatory patients in a randomized, double-blind, placebo-controlled, 12-week trial of three RIS dosages (0.5 mg/day, 1 mg/day, 2 mg/day). Outcomes included number of fallers, rate of falls, and time until the first fall after randomization. Additional analyses evaluated wandering as a potential moderating or mediating variable. The ambulatory sample included 537 subjects. Of those, 22.3% on placebo, 18.0% on RIS 0.5 mg/day, 12.7% on 1 mg/day, and 27.3% on 2 mg/day, respectively, fell during the trial. The difference between the RIS 1 mg/day group and placebo was significant, with a significantly lower hazard ratio in the RIS 1-mg/day group than placebo. Wandering was associated with an increased risk of falls. Among 205 patients with the highest levels of wandering at baseline, RIS 1 mg/day was associated with approximately a 70% reduction in risk for falls versus placebo condition. However, in those with the lowest levels of wandering at baseline, RIS 2 mg/day may have increased the risk of falls. Evaluating the benefits versus risks of risperidone in...Continue Reading

Citations

Oct 9, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sirpa HartikainenKirsti Louhivuori
Dec 1, 2006·International Journal of Older People Nursing·Donna L Algase
Aug 10, 2007·Expert Opinion on Pharmacotherapy·Arun V RavindranTricia L da Silva
Oct 26, 2012·Pharmacoepidemiology and Drug Safety·Thomas K BauerFrank Verheyen
Oct 30, 2019·Health Technology Assessment : HTA·Louise M AllanClaire Bamford

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