Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats

Neurotoxicology
Katsutoshi ShiodaSatoshi Kato

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a widely used recreational drug. Despite an increase in the number of fatalities related to its use, no definite therapeutic method has been established thus far. In the present study, risperidone's ability to attenuate MDMA-induced hyperthermia and its mechanism of action were investigated in rats. The pharmacological effect of MDMA was evaluated using microdialysis. In the body temperature experiment, administration of risperidone before and after MDMA administration significantly suppressed MDMA-induced hyperthermia in a dose-dependent fashion. Furthermore, risperidone completely inhibited MDMA-induced hyperthermia at a low ambient temperature. Moreover, pretreatment with ritanserin, ketanserin, or R-96544, all of which are 5-HT(2A)-receptor antagonists, significantly prevented MDMA-induced hyperthermia. On the other hand, pretreatment with WAY-100635 (a 5-HT(1A) receptor antagonist), SB 206553 (a 5-HT(2B/2C) receptor antagonist), or SB 242084 (a 5-HT(2C) receptor antagonist) did not prevent MDMA-induced hyperthermia. Pretreatment with haloperidol, which blocks the dopamine (DA) receptors D(2) and D(1), significantly prevented MDMA-induced hyperthermia. However, sulpirid...Continue Reading

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Citations

Apr 18, 2009·Molecular Neurobiology·João Paulo CapelaFélix Carvalho
Aug 30, 2011·The Australian and New Zealand Journal of Psychiatry·Esther BlessingChristos Pantelis
Mar 5, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph M HerndonTerrence J Monks
Nov 13, 2012·Neuroscience Letters·Koichi NisijimaSatoshi Kato
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Jul 27, 2010·Neuroscience Letters·Katsutoshi ShiodaSatoshi Kato
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Aug 22, 2020·The International Journal of Neuropsychopharmacology·Tsuyoshi OkadaShiro Suda
Apr 4, 2017·Korean journal of anesthesiology·Soohyun JoeHyun Kim

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