Abstract
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a widely used recreational drug. Despite an increase in the number of fatalities related to its use, no definite therapeutic method has been established thus far. In the present study, risperidone's ability to attenuate MDMA-induced hyperthermia and its mechanism of action were investigated in rats. The pharmacological effect of MDMA was evaluated using microdialysis. In the body temperature experiment, administration of risperidone before and after MDMA administration significantly suppressed MDMA-induced hyperthermia in a dose-dependent fashion. Furthermore, risperidone completely inhibited MDMA-induced hyperthermia at a low ambient temperature. Moreover, pretreatment with ritanserin, ketanserin, or R-96544, all of which are 5-HT(2A)-receptor antagonists, significantly prevented MDMA-induced hyperthermia. On the other hand, pretreatment with WAY-100635 (a 5-HT(1A) receptor antagonist), SB 206553 (a 5-HT(2B/2C) receptor antagonist), or SB 242084 (a 5-HT(2C) receptor antagonist) did not prevent MDMA-induced hyperthermia. Pretreatment with haloperidol, which blocks the dopamine (DA) receptors D(2) and D(1), significantly prevented MDMA-induced hyperthermia. However, sulpirid...Continue Reading
References
Nov 13, 1992·European Journal of Pharmacology·C J SchmidtV L Taylor
Sep 1, 1988·Japanese Journal of Pharmacology·J YamadaK Horisaka
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1995·Psychopharmacology·P Mazzola-PomiettoD L Murphy
Feb 1, 1996·British Journal of Pharmacology·G A KennettT P Blackburn
Sep 1, 1996·Intensive Care Medicine·K J Dar, M E McBrien
Mar 1, 1996·Psychopharmacology·A SchotteJ E Leysen
Apr 1, 1997·Neuropharmacology·G A KennettT P Blackburn
Sep 16, 1998·Annals of Emergency Medicine·P D Mueller, W S Korey
Jun 27, 2000·Psychopharmacology·K NisijimaT Ishiguro
Dec 5, 2000·Behavioural Pharmacology·M C Wolff, J D Leander
Aug 22, 2001·European Journal of Pharmacology·A W SchmidtS H Zorn
Jan 12, 2002·British Journal of Pharmacology·Annis O MechanA Richard Green
Oct 31, 2002·Human Psychopharmacology·A. C. Parrott
Dec 5, 2002·European Journal of Pharmacology·Taketoshi OgawaFumitoshi Asai
Jan 11, 2003·BMJ : British Medical Journal·Fabrizio SchifanoA Hamid Ghodse
Feb 27, 2003·Addiction·Erkki VuoriMatti Jäntti
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Lynda UphouseWilliam A Truitt
Apr 10, 2004·Drug and Alcohol Dependence·Sotiria BexisRodney J Irvine
Jul 28, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Katsutoshi ShiodaSatoshi Kato
Mar 15, 2005·Psychopharmacology·David V HerinKathryn A Cunningham
Jun 9, 2005·Critical Care Medicine·Jon E SpragueEdward M Mills
Jun 30, 2005·Psychopharmacology·William Walter Blessing
Jul 30, 2005·British Journal of Anaesthesia·P K Gillman
Sep 16, 2005·Psychopharmacology·Robert R FreedmanManuel E Tancer
Oct 18, 2005·The Medical Clinics of North America·Daniel E Rusyniak, Jon E Sprague
Apr 6, 2006·British Journal of Anaesthesia·A P Hall, J A Henry
Aug 22, 2006·CNS & Neurological Disorders Drug Targets·Martyn D WoodDeclan N C Jones
Jun 15, 2007·Synapse·Yukio AgoToshio Matsuda
Jul 11, 2007·The Australian and New Zealand Journal of Psychiatry·Edmund SilinsPaul Dillon
Citations
May 4, 2010·Psychopharmacology·Natacha Vanattou-SaïfoudineAndrew Harkin
Jun 26, 2010·Psychopharmacology·Vicky KatsidoniGeorge Panagis
Apr 18, 2009·Molecular Neurobiology·João Paulo CapelaFélix Carvalho
Dec 4, 2009·PloS One·Stéphane DolyLuc Maroteaux
Aug 30, 2011·The Australian and New Zealand Journal of Psychiatry·Esther BlessingChristos Pantelis
Mar 5, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph M HerndonTerrence J Monks
Mar 7, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lucina E LizarragaTerrence J Monks
Nov 13, 2012·Neuroscience Letters·Koichi NisijimaSatoshi Kato
Sep 19, 2012·Neuroscience Letters·Katsutoshi ShiodaSatoshi Kato
May 31, 2011·Neuroscience Letters·Makiko KasaiSatoshi Kato
Oct 5, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Allison A FeducciaChristine L Duvauchelle
Jul 27, 2010·Neuroscience Letters·Katsutoshi ShiodaSatoshi Kato
May 19, 2009·Drug and Alcohol Dependence·Petra S van Nieuwenhuijzen, Iain S McGregor
Mar 13, 2012·British Journal of Pharmacology·Cm HysekM E Liechti
Oct 10, 2012·British Journal of Pharmacology·S E ShortallM V King
Aug 3, 2013·Autonomic & Autacoid Pharmacology·J R Docherty, S Bexis
Jul 2, 2010·British Journal of Pharmacology·J R Docherty, A R Green
Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eugene A KiyatkinYavin Shaham
Jul 31, 2013·Brain Research Bulletin·C Roger-SánchezM A Aguilar
Jun 15, 2010·Drug and Alcohol Dependence·Katsutoshi ShiodaSatoshi Kato
Jul 16, 2011·Neurochemistry International·Csaba AdoriGyörgy Bagdy
Oct 11, 2014·Psychopharmacology·Rui TaoZhiyuan Ma
Nov 6, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lucina E LizarragaTerrence J Monks
Nov 20, 2016·PloS One·Dina PopovaStig O P Jacobsson
Dec 19, 2017·Psychopharmacology·Elizabeth G PittsLeonard L Howell
Oct 4, 2012·Critical Reviews in Toxicology·Saskia J RietjensJan Meulenbelt
Aug 22, 2020·The International Journal of Neuropsychopharmacology·Tsuyoshi OkadaShiro Suda
Apr 4, 2017·Korean journal of anesthesiology·Soohyun JoeHyun Kim
Aug 7, 2019·BMC Pharmacology & Toxicology·Ibrahim M ShokryRui Tao
Oct 11, 2017·Neuropharmacology·Daniel W CurryLeonard L Howell