Risperidone Attenuates Modified Stress-Re-stress Paradigm-Induced Mitochondrial Dysfunction and Apoptosis in Rats Exhibiting Post-traumatic Stress Disorder-Like Symptoms

Journal of Molecular Neuroscience : MN
Debapriya GarabaduSairam Krishnamurthy

Abstract

Mitochondria play a significant role in the pathophysiology of post-traumatic stress disorder (PTSD). Risperidone and paroxetine were evaluated for their effect on mitochondrial dysfunction and mitochondria-dependent apoptosis in discrete brain regions in modified stress re-stress (SRS) animal model of PTSD. Male rats were subjected to stress protocol of 2 h restraint and 20 min forced swim followed by halothane anesthesia on day 2 (D-2). Thereafter, rats were exposed to re-stress (forced swim) on D-8 and at 6-day intervals on D-14, D-20, D-26, and D-32. The rats were treated with risperidone (0.01, 0.1, and 1.0 mg/kg p.o.) and paroxetine (10.0 mg/kg p.o.) from D-8 to D-32. Risperidone at median dose and paroxetine ameliorated modified SRS-induced depressive-like symptom (increase in immobility period) in forced swim, anxiety-like behavior (decrease in percentage of open arm entries and time spent) in elevated plus maze and cognitive deficits (loss in spatial recognition memory) in Y-maze tests on D-32. Risperidone, but not paroxetine, attenuated modified SRS-induced decreases in plasma corticosterone levels. Risperidone ameliorated increase in the activity of mitochondrial respiratory complex (I, II, IV, and V), decreases in t...Continue Reading

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Citations

Mar 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefania Schiavone, Luigia Trabace
Apr 2, 2016·Journal of Molecular Neuroscience : MN·Cécile MonpaysSylvain Grignon
Mar 10, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Bombi LeeDae-Hyun Hahm
Jan 9, 2019·Frontiers in Psychiatry·Yinan WuAnwen Shao
Jan 4, 2021·Pharmacological Reports : PR·Santosh Kumar Prajapati, Sairam Krishnamurthy
Jul 20, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L HolperJ J Mann
Sep 4, 2019·Physiology & Behavior·Santosh Kumar PrajapatiSairam Krishnamurthy
Apr 10, 2018·Biological Psychiatry·Synthia H MellonOwen M Wolkowitz

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