Risperidone does not elevate neurotensin mRNA in rat nucleus accumbens and caudate-putamen

Neuroreport
M J MijnsterP Voorn

Abstract

The ability of the novel antipsychotic drug risperidone to alter striatal neurotensin mRNA levels was investigated and compared with the typical antipsychotic drug haloperidol. Quantitative in situ hybridization studies revealed that risperidone treatment does not affect neurotensin mRNA levels in nucleus accumbens or caudate-putamen. This absence of effect contrasts with the dramatic increases in neurotensin mRNA seen after haloperidol treatment in these brain regions. Our results, while conforming the atypical nature of risperidone, do not support the notion that neurotensin elevation in the nucleus accumbens is necessary for the development of an antipsychotic effect.

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.