Risperidone for children and adolescents with autism spectrum disorder: a systematic review

Neuropsychiatric Disease and Treatment
Narong ManeetonManit Srisurapanont

Abstract

Various clinical trials suggested that risperidone was beneficial in the treatment of autism spectrum disorder (ASD) in children and adolescents. The aim of this systematic review was to determine the efficacy, acceptability and tolerability of risperidone in the treatment of children and adolescents with ASD. The databases of Scopus, PubMed, CINAHL and Cochrane Controlled Trials Register were searched in February 2017. Eligible RCTs of risperidone in the treatment of child and adolescent patients with ASD. Languages were not restricted. The full-text versions of relevant studies were thoroughly assessed and extracted. The primary efficacy of outcome was the pooled response rate and the pooled mean changed scores of the standardized rating scales for ASD. A total of 372 randomized subjects from seven RCTs were included in this review. In acute treatment, the pooled mean change score of the Aberrant Behavior Checklist for irritability subscale (ABC-I) and response rate for the risperidone-treated group had a greater significance than that of the placebo-treated group. In the long-term treatment, the pooled mean change score of the CARS in the risperidone-treated group was significantly greater than that in the placebo-treated gr...Continue Reading

Citations

Feb 7, 2020·Neurotoxicity Research·Raju PaudelShamsher Singh
Nov 6, 2020·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Narges SharifzadehMaliheh Ziaee
Jan 27, 2021·Health and Quality of Life Outcomes·Gian Loreto D'AlòUNKNOWN ISACAGuideline Working Group
Feb 2, 2021·Frontiers in Cellular Neuroscience·Tanya Gandhi, Charles C Lee
Mar 12, 2021·Pharmacological Reports : PR·Priya JoonMilind Parle
Dec 6, 2020·Neuroscience Letters·Yunyun CaiGang Chen
May 19, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Christoph U CorrellMarco Solmi
Jul 28, 2021·Primary Care·Ashley Iles
Nov 24, 2021·Autism Research : Official Journal of the International Society for Autism Research·Laura TurrizianiAntonio M Persico

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