Risperidone-induced symptomatic hyperprolactinaemia in adolescents

Journal of Clinical Psychopharmacology
Laurent Holzer, Chin B Eap

Abstract

Studies performed in adult patients unambiguously demonstrate a marked effect of risperidone on prolactin blood levels, with possible clinical effects related to hyperprolactinemia, such as gynecomastia and galactorrhea. However, the largest study performed in children and adolescents showed a weak effect of risperidone on prolactin concentrations during short-term treatment and a negligible effect during long-term treatment, which was probably because of the relatively low dosages of risperidone used [approximately 0.04 mg/(kg x d)]. Among the 10 psychotic adolescents treated with risperidone in our unit, we had 3 cases of gynecomastia in 3 male patients and 2 cases of galactorrhea in 2 female patients. The prolactin blood levels in these cases and in 3 other patients without apparent prolactin-related side effects were all above the normal range (median, 59 ng/mL; range, 30-123 ng/mL). Thus, risperidone administered to adolescents at doses commonly used for the treatment of psychotic symptoms can strongly increase prolactin levels, with clinical consequences such as gynecomastia and/or galactorrhea. Given that the long-term effects of antipsychotic drug-induced hyperprolactinemia are not well documented, especially regarding ...Continue Reading

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Citations

Apr 12, 2008·Pituitary·Mark E Molitch
Sep 28, 2010·International Journal of Pediatric Endocrinology·Arlan L Rosenbloom
Dec 5, 2009·CNS Drugs·Chaya G BhuvaneswarJonathan E Alpert
Jun 25, 2013·Expert Opinion on Drug Metabolism & Toxicology·Francesca MaranghiAlberto Mantovani
Oct 9, 2012·Child and Adolescent Psychiatric Clinics of North America·Ann E MaloneyJean A Frazier

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