Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine

British Journal of Pharmacology
P HertelT H Svensson

Abstract

1. The effects of risperidone on brain 5-hydroxytryptamine (5-HT) neuronal functions were investigated and compared with other antipsychotic drugs and selective receptor antagonists by use of single cell recording and microdialysis in the dorsal raphe nucleus (DRN). 2. Administration of risperidone (25-400 micrograms kg-1, i.v.) dose-dependently decreased 5-HT cell firing in the DRN, similar to the antipsychotic drug clozapine (0.25-4.0 mg kg-1, i.v.), the putative antipsychotic drug amperozide (0.5-8.0 mg kg-1, i.v.) and the selective alpha 1-adrenoceptor antagonist prazosin (50-400 micrograms kg-1, i.v.). 3. The selective alpha 2-adrenoceptor antagonist idazoxan (10-80 micrograms kg-1, i.v.), in contrast, increased the firing rate of 5-HT neurones in the DRN, whereas the D2 and 5-HT2A receptor antagonists raclopride (25-200 micrograms kg-1, i.v.) and MDL 100,907 (50-400 micrograms kg-1, i.v.), respectively, were without effect. Thus, the alpha 1-adrenoceptor antagonistic action of the antipsychotic drugs might, at least partly, cause the decrease in DRN 5-HT cell firing. 4. Pretreatment with the selective 5-HT1A receptor antagonist WAY 100,635 (5.0 micrograms kg-1, i.v.), a drug previously shown to antagonize effectively the ...Continue Reading

References

Oct 1, 1976·European Journal of Pharmacology·D W Gallager, G K Aghajanian
Jan 25, 1991·European Journal of Pharmacology·J C GarrattC A Marsden
Jan 1, 1992·Physiological Reviews·B L Jacobs, E C Azmitia
Jan 1, 1990·The Journal of Neuropsychiatry and Clinical Neurosciences·M B Goldman, H M Janecek
Jan 1, 1990·Pharmacology & Toxicology·J Svartengren, P Simonsson
Jul 1, 1989·Physiological Reviews·K StarkeH Kilbinger
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Oct 15, 1984·European Journal of Pharmacology·J E Freedman, G K Aghajanian
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·T SumiyoshiK Yokogawa
Jan 1, 1994·International Clinical Psychopharmacology·E SpinaA P Caputi
Nov 25, 1993·Nature·D L Cameron, J T Williams
May 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·R E LitmanD Pickar
Jul 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P HertelT H Svensson

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Citations

Apr 20, 2000·European Journal of Pharmacology·F J NasifO A Ramirez
Sep 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patricia A BroderickYueping Zhou
Sep 2, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·P HertelT H Svensson
Mar 1, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Olga ChernolozPierre Blier
Aug 25, 2012·Expert Opinion on Investigational Drugs·Gaël QuesseveurBruno P Guiard
Dec 14, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ramez GhanbariPierre Blier
Jan 1, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ramez GhanbariPierre Blier
Dec 27, 2011·Neuropharmacology·Caroline E McCardle, Sarah E Gartside
Aug 1, 2014·Behavioural Brain Research·Davide Amato
Oct 12, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·George S AlexopoulosCharles Reynolds
Feb 17, 2018·Pharmaceutical Research·Willem Johan van den BrinkElizabeth Cunera Maria de Lange
Mar 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Bortolozzi, F Artigas

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