Risperidone long-acting injection: pharmacokinetics following administration in deltoid versus gluteal muscle in schizophrenic patients

Journal of Clinical Pharmacology
An ThyssenE Mannaert

Abstract

Long-acting injectable (LAI) risperidone for intramuscular injection into the gluteal muscle every 2 weeks is approved for schizophrenia. The deltoid muscle provides a more accessible injection site and could therefore facilitate patient acceptance of an injectable medication. Two studies in chronic schizophrenic subjects evaluated the pharmacokinetics and tolerability of LAI risperidone administered into the deltoid muscle. The pharmacokinetics following deltoid injection and bioequivalence between deltoid and gluteal administration were assessed in an open-label, single-dose, crossover, fully powered bioavailability study. Tolerability and safety of deltoid LAI risperidone were investigated in an open-label multiple-dose study in subjects who were previously being treated with gluteal injections of LAI risperidone. Patients received 4 sequential intramuscular injections of LAI risperidone, administered every 2 weeks into the deltoid muscle. Deltoid and gluteal injections of LAI risperidone were shown to be bioequivalent at equal doses with respect to peak and total plasma exposure and exhibited dose-proportional pharmacokinetics, independent of injection site. In addition, deltoid injection was safe and well tolerated. Inject...Continue Reading

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Citations

Feb 22, 2014·Pharmaceutical Research·Sara Montminy PaquetteDaniel R Deaver
Jun 28, 2016·Expert Opinion on Drug Safety·L OrsoliniD De Berardis
Jul 13, 2017·Expert Review of Clinical Pharmacology·Georgios SchoretsanitisJose de Leon
Nov 2, 2014·Therapeutic Advances in Psychopharmacology·Sofia BrissosVicent Balanzá-Martinez
Oct 28, 2010·Expert Review of Neurotherapeutics·William V Bobo, Richard C Shelton
May 24, 2020·Current Pharmaceutical Design·Ece Ö BülbülNeslihan Ü Okur
Nov 17, 2020·Therapeutic Drug Monitoring·Georgios SchoretsanitisChristoph Hiemke

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