PMID: 7545034Jun 1, 1995Paper

Risperidone: review and assessment of its role in the treatment of schizophrenia

The Annals of Pharmacotherapy
A A Cardoni

Abstract

To review pharmacologic, pharmacokinetic, therapeutic, and safety information for the antipsychotic agent risperidone and to evaluate its place in the treatment of schizophrenia. MEDLINE and Exerpta Medica databases; Janssen Pharmaceuticals; Food and Drug Administration Psychopharmacology Advisory Committee; PJB Publications; published articles and abstracts; unpublished research reports and abstracts. In vivo animal studies (pharmacology); volunteer studies (pharmacokinetics); clinical case reports, open clinical studies, and controlled clinical studies (clinical efficacy and adverse effects; long-term studies; studies in special populations. Relevant data were extracted from published and unpublished source documents, evaluated, and summarized in tables for comparative review. Abstracts were used in 6 of 8 pharmacokinetic studies, 4 of 8 open clinical studies, and 2 of 9 controlled clinical studies. Use of abstracts limits the extent of data extracted. Risperidone is an effective treatment for positive symptoms of schizophrenia and may be effective for negative symptoms. Efficacy in treatment-resistant patients is inconclusive. In patients in whom low-to-moderate dosage is effective, there should be fewer and less severe adve...Continue Reading

Citations

Dec 10, 1997·The Annals of Pharmacotherapy·J C KandoA I Green
Feb 11, 1999·The Annals of Pharmacotherapy·J S MarkowitzT R Moore
May 4, 1999·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·O Blin
Oct 24, 2007·Acta Psychiatrica Scandinavica. Supplementum·E LindströmS Levander
Mar 1, 1996·The Annals of Pharmacotherapy·J L Kern, P K Cernek
Jan 5, 2001·European Child & Adolescent Psychiatry·H RemschmidtE Schulz
Dec 16, 2003·Hospital Medicine·James Paul Pandarakalam
Apr 4, 2000·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·H RemschmidtE Schulz
Jul 1, 1997·The Annals of Pharmacotherapy·D S Ravin, J W Levenson
Jul 1, 1997·Administration and Policy in Mental Health·D Starkey, B A Leadholm

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