Risperidone treatment for ADHD in children and adolescents with bipolar disorder.

Neuropsychiatric Disease and Treatment
J BiedermanE Mick

Abstract

Children and adolescents with bipolar disorder are also at high risk of having comorbid attention-deficit hyperactivity disorder (ADHD). The objective of this study was to estimate improvement in ADHD symptoms in children with bipolar disorder. This was an open-label, study of risperidone monotherapy for the treatment of pediatric bipolar disorder. Thirty-one children and adolescents 4-15 years of age (7.2 +/- 2.8 years) of both sexes (71%, N = 22 male) with pediatric bipolar disorder (YMRS score = 32.9 +/- 8.8) and ADHD (ADHD-RS score = 37.9 +/- 8.9) were included in these analyses. Improvement in ADHD symptoms was contingent on improvement in manic symptoms. Although both hyperactive/impulsive (-7.5 +/- 5.5.6, p < 0.05) and inattentive (-6.8 +/- 5.0, p < 0.05) ADHD symptoms were significantly improved with risperidone, improvement was modest, and only 29% of subjects (N = 6) showed a 30% reduction in ADHD rating scale scores and had a CGI-I </= 2. These results suggest that that treatment with risperidone is associated with tangible but generally modest improvement of symptoms of ADHD in children with bipolar disorder.

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Citations

Dec 30, 2014·Journal of Affective Disorders·Álvaro FríasNúria Farriols
Jun 21, 2015·Child and Adolescent Psychiatric Clinics of North America·Andrea S Young, Mary A Fristad
Feb 20, 2010·Journal of Child and Adolescent Psychopharmacology·Gagan JoshiJoseph Biederman
May 10, 2012·Current Opinion in Psychiatry·Philip Hazell, Rajeev Jairam
Jun 7, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Covadonga M Díaz-CanejaDolores Moreno
Nov 28, 2008·Annual Review of Psychology·W Andrew CollinsWyndol Furman
Jul 1, 2010·Expert Review of Neurotherapeutics·Vanya Hamrin, Joanne DeSanto Iennaco
May 29, 2013·Current Psychiatry Reports·Caroly Pataki, Gabrielle A Carlson
Sep 8, 2020·Expert Opinion on Drug Safety·Felice IasevoliAndrea de Bartolomeis

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BETA
sedation
pharmacotherapy

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STATA

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