PMID: 9555596Apr 29, 1998Paper

Risperidone versus haloperidol and amitriptyline in the treatment of patients with a combined psychotic and depressive syndrome

Journal of Clinical Psychopharmacology
F Müller-SiechenederO Benkert

Abstract

In a multicenter, double-blind, parallel group trial, the efficacy of risperidone (RIS) was compared with a combination of haloperidol and amitriptyline (HAL/AMI) over 6 weeks in patients with coexisting psychotic and depressive symptoms with either a schizoaffective disorder, depressive type, a major depression with psychotic features, or a nonresidual schizophrenia with major depressive symptoms according to DSM-III-R criteria. A total of 123 patients (62 RIS; 61 HAL/AMI) were included; the mean daily dosage at endpoint was 6.9 mg RIS versus 9 mg HAL combined with 180 mg AMI. Efficacy results for those 98 patients (47 RIS; 51 HAL/AMI) who completed at least 3 weeks of double-blind treatment revealed in both treatment groups large reductions in the Positive and Negative Syndrome Scale-derived Brief Psychiatric Rating Scale (RIS 37%; HAL/AMI 51%) and the Bech-Rafaelsen Melancholia Scale total scores (RIS 51%; HAL/AMI 70%). The reductions in the Brief Psychiatric Rating Scale and the Bech-Rafaelsen Melancholia Scale scores in the total group were significantly larger in the HAL/AMI group than in the RIS group (p < 0.01), mostly because of significant differences in the subgroup of patients suffering from depression with psychoti...Continue Reading

References

Jan 1, 1992·Journal of Affective Disorders·G ParkerF Pedic
Jul 1, 1992·Biological Psychiatry·S Kapur, J J Mann
Oct 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·I F BrockingtonR Hawley
Jan 1, 1988·Schizophrenia Bulletin·A BleichH M van Praag
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1984·Schizophrenia Bulletin·P J Goodnick, H Y Meltzer
Jun 1, 1994·The American Journal of Psychiatry·S R Marder, R C Meibach
May 1, 1994·Psychopharmacology·P E KeckS A West
Apr 1, 1996·The American Journal of Psychiatry·S Kapur, G Remington
Oct 1, 1996·Psychopharmacology·P StathisD Varonos
Jun 1, 1997·Journal of Clinical Psychopharmacology·G M Simpson, J P Lindenmayer

❮ Previous
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Citations

Apr 7, 2005·European Archives of Psychiatry and Clinical Neuroscience·Hans-Jürgen Möller
Dec 21, 2000·Current Psychiatry Reports·C A ZarateM Land
Dec 21, 2000·Current Psychiatry Reports·B L O'NealM Trivedi
Apr 23, 2003·Biological Psychiatry·Anthony J Rothschild
Jul 20, 2001·Journal of Psychiatric Research·I D GlickR J Hu
Sep 12, 2001·The Australian and New Zealand Journal of Psychiatry·G Parker, G Malhi
Mar 14, 2007·Cognitive Neuropsychiatry·Christian G Kohler, Elizabeth A Martin
Sep 29, 2001·Clinical Neuropharmacology·C Miodownik, V Lerner
Sep 28, 2002·Journal of Clinical Psychopharmacology·Hsien-Yuan LaneWen-Ho Chang
Feb 24, 2001·International Clinical Psychopharmacology·I Schweitzer
Jul 3, 2004·Journal of Clinical Psychopharmacology·Anthony J RothschildGary D Tollefson
Aug 11, 2007·International Clinical Psychopharmacology·A Carlo AltamuraHerbert Y Meltzer
Jun 27, 2009·Neuropsychiatric Disease and Treatment·Lubomira IzákováAngelos Halaris
Jan 5, 2002·CNS Drugs·Daniel TarsyFrank I Tarazi
Jan 25, 2011·CNS Drugs·John KasckowSidney Zisook
Oct 27, 2011·Aging Health·John KasckowSidney Zisook
Mar 21, 2001·Bipolar Disorders·S N GhaemiF K Goodwin
Aug 20, 2014·The Medical Clinics of North America·L Renata Thronson, Genevieve L Pagalilauan
Jul 14, 2000·Current Medical Research and Opinion·B Green
Jul 3, 2009·Acta Psychiatrica Scandinavica·M JägerK Frasch
May 29, 2015·Acta Psychiatrica Scandinavica·S D ØstergaardB S Meyers
Apr 4, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Makiko GotoJun Nakamura
Aug 10, 2007·Expert Opinion on Pharmacotherapy·Arun V RavindranTricia L da Silva
Jun 7, 2005·Expert Opinion on Pharmacotherapy·Hans-Jürgen Möller
Jun 22, 2002·The Cochrane Database of Systematic Reviews·C WhiteheadG Lewis
Dec 15, 2010·The Cochrane Database of Systematic Reviews·Katja KomossaStefan Leucht
Aug 1, 2015·The Cochrane Database of Systematic Reviews·Jaap WijkstraWillem A Nolen
Feb 7, 2008·The Cochrane Database of Systematic Reviews·V A Furtado, V Srihari
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·H J Möller
Jan 1, 2008·International Journal of Psychiatry in Clinical Practice·Mazda AdliMichael Bauer
Feb 18, 2004·Harvard Review of Psychiatry·Carrie L Ernst, Joseph F Goldberg
Feb 28, 2003·Psychopharmacology·Paolo BrambillaJair C Soares
Jun 7, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Audrey R TyrkaLinda L Carpenter
Dec 1, 2020·Schizophrenia Bulletin·Damien Etchecopar-EtchartGuillaume Fond
Jan 2, 2007·Journal of Psychosocial Nursing and Mental Health Services·Robert H Howland

❮ Previous
Next ❯

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