Ritanserin decreases portal pressure in conscious and unrestrained cirrhotic rats

Gastroenterology
R MastaiP M Huet

Abstract

We have recently demonstrated that ritanserin, a serotonin 5-hydroxytryptamine receptor antagonist void of systemic effects, caused a significant reduction of portal pressure in conscious cirrhotic dogs. The mechanism by which ritanserin lowers portal pressure is poorly defined. We investigated the splanchnic and systemic hemodynamic effects of ritanserin (0.63 mg/kg body wt i.v., a dose known to completely inhibit binding of 5-hydroxytryptamine to its receptors), in conscious and unrestrained cirrhotic rats (n = 13). Heparinized catheters were placed into the portal vein, inferior vena cava, aorta, and left ventricle with exit from the neck. Hemodynamic studies were performed 4 h after consciousness was regained. Cardiac output and regional blood flows were measured using radiolabeled microspheres and the reference sample method. Sixty minutes after administration, ritanserin caused a significant reduction of portal pressure (-17%) with minimal changes in portal venous inflow (+3%). Portal vascular resistance decreased significantly (-23%), whereas splanchnic arteriolar resistance was similar before and after ritanserin. A significant increase in mean arterial pressure (+5%) and cardiac output (+22%) was observed. Our results ...Continue Reading

Citations

Jun 1, 1995·Journal of Clinical Pharmacology·W H FrishmanB Shareef
May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Pomier-LayrarguesP M Huet
Dec 22, 1998·The American Journal of Gastroenterology·H M Shahi, S K Sarin
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R MehtaA T Blei
Oct 1, 1992·Alimentary Pharmacology & Therapeutics·R D Grose, P C Hayes
Oct 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P BeaudryD Lebrec
Aug 23, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·L DagherA Burroughs

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