PMID: 8956382Nov 1, 1996Paper

Ritanserin in the treatment of alcohol dependence--a multi-center clinical trial. Ritanserin Study Group

Psychopharmacology
Bankole A JohnsonC Clyde

Abstract

Four hundred and twenty-three alcohol dependent subjects were enrolled into a 12-week randomized, double-blind, placebo-controlled study to determine the safety and efficacy of the 5-HT2 receptor antagonist, ritanserin (2.5 mg/day or 5 mg/day), in reducing alcohol intake and craving. All subjects received 1 week of single-blind placebo prior to randomization into the 11-week double-blind phase. Additionally, all subjects received weekly individual sessions of manual-guided cognitive-behavioral therapy. Comparing the single-blind period with endpoint, there was approximately a 23% reduction in drinks/day; 34% fall in the total number of drinking days/week; 22% decrease in drinks/drinking day; and a 37% diminution in alcohol craving for all treatment groups. All treatment groups experienced a beneficial clinical outcome as assessed by the Clinical Global Impression Scale. There was, however, no significant difference between treatment groups on any of these measures of alcohol drinking, craving, or clinical outcome. Subjects were of relatively high social functioning at baseline, and this did not change significantly during treatment. Treatment groups did not differ significantly on either medication compliance or reported advers...Continue Reading

Citations

Mar 10, 2001·Journal of Substance Abuse Treatment·J P Allen, R Z Litten
Apr 6, 1999·Schizophrenia Research·J H KrystalI L Petrakis
Sep 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M Soyka, J De Vry
May 13, 1999·The New England Journal of Medicine·R M Swift
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Charles P O'Brien
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·M K RomachB Gomez-Mancilla
Mar 10, 2001·Alcoholism, Clinical and Experimental Research·B A FlanneryD J Rohsenow
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·J P AllenP Sillanaukee
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·I L PetrakisJ H Krystal
Jun 18, 2002·Alcoholism, Clinical and Experimental Research·Andrea C KingAlyson Schuster
Mar 15, 2005·Harvard Review of Psychiatry·John J Mariani, Frances R Levin
Nov 12, 2005·Substance Use & Misuse·Alessandra Buonopane, Ismene L Petrakis
Feb 20, 2004·The American Journal on Addictions·Mary E McCaul, Nancy M Petry
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·Chinnaswamy KasinathanPaul Manowitz
Jan 18, 2007·Fundamental & Clinical Pharmacology·Sophie Tambour, Etienne Quertemont
Mar 31, 2012·Addiction Biology·Raye Z LittenAntonio Noronha
Jun 17, 2011·Alcoholism, Clinical and Experimental Research·Jennifer K PenberthyBankole A Johnson
Nov 4, 2005·European Journal of Pharmacology·Falk Kiefer, Karl Mann
Aug 8, 2014·Addiction·Robert L StoutUNKNOWN ACTIVE group
Apr 28, 2006·Yonsei Medical Journal·Young-Chul Jung, Kee Namkoong
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Apr 8, 2011·British Journal of Pharmacology·Tamzin L Ripley, David N Stephens
Feb 21, 2021·Cancer Immunology Research·Lingyi FuPenghui Zhou

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