Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences

Kidney International
G L BradenB L Haag

Abstract

The effects of ritodrine and terbutaline on potassium homeostasis, renal function, and cardiac rhythm were assessed in women treated with these drugs for preterm labor. Timed blood and urine samples were obtained for two hours before and during six hours of intravenous ritodrine (N = 5) and terbutaline (N = 5) administered in pharmacologically equivalent doses. No differences were found in any parameters affecting potassium homeostasis or renal function between these drugs. A decrease in mean plasma potassium of 0.9 mEq/liter occurred after 30 minutes of drug infusion (4.2 +/- 0.1 to 3.3 +/- 0.1 mEq/liter, P < 0.005) before any significant changes in plasma glucose (75.0 +/- 4.7 to 93.7 +/- 6.1 mg/dl, P = NS) or plasma insulin (12.4 +/- 6.0 to 28.4 +/- 5.1 mU/ml, P = NS). The mean plasma potassium after four hours of drug infusion was 2.5 +/- 0.1 mEq/liter. Plasma insulin rose to a level known to induce cellular potassium uptake (39.2 +/- 7.7 mU/ml) after 60 minutes of drug therapy and remained at this level for four hours. Hyperlactatemia occurred at four hours (4.7 +/- 0.8 mmol/liter) and the plasma lactate/pyruvate ratio increased in a 10:1 ratio. Both drugs significantly reduced glomerular filtration rate, sodium, potassium...Continue Reading

References

Jan 9, 1975·The New England Journal of Medicine·R W Schrier, T Berl
Apr 15, 1977·American Journal of Obstetrics and Gynecology·N H LauersenF Fuchs
Jun 1, 1977·The Journal of Clinical Endocrinology and Metabolism·D S Schade, R P Eaton
May 1, 1977·British Journal of Obstetrics and Gynaecology·S K Smith, D Thompson
Dec 1, 1976·The American Journal of Physiology·V S LimM D Lindheimer
Jan 16, 1975·The New England Journal of Medicine·R W Schrier, T Berl
Feb 1, 1975·Postgraduate Medical Journal·R GoldbergH C Seftel
May 1, 1976·The Journal of Clinical Endocrinology and Metabolism·S M Guerra, A E Kitabchi
Oct 1, 1991·Kidney International·I Ichikawi, R C Harris
Jan 1, 1991·American Journal of Nephrology·M UsbertiS Ghielmi
Jan 10, 1985·The New England Journal of Medicine·L VanheesA Amery
May 1, 1986·The Journal of Clinical Endocrinology and Metabolism·Y KawaiI J Arinze
Jul 1, 1986·Kidney International·R S Brown
Sep 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N E MadiasS Herson
May 1, 1985·The American Journal of Physiology·D A YoungJ O Holloszy
Oct 3, 1985·The New England Journal of Medicine·G L BradenJ A Dawson
Nov 1, 1973·The Journal of Clinical Investigation·N F GantP C MacDonald
Jun 1, 1971·The American Journal of Physiology·E P Todd, R L Vick
Feb 21, 1980·The New England Journal of Medicine·R M RosaF H Epstein
May 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·G GrospietschW Kuhn
Jan 1, 1980·Physiological Reviews·D A Hems, P D Whitton
Dec 8, 1983·The New England Journal of Medicine·M J BrownM B Murphy
Sep 1, 1984·American Journal of Obstetrics and Gynecology·S N CaritisG Ashmead
May 1, 1983·American Journal of Obstetrics and Gynecology·S R RichardsL E Stempel
Jan 1, 1983·American Journal of Obstetrics and Gynecology·T J Benedetti
Jan 1, 1983·American Journal of Obstetrics and Gynecology·D C YoungK J Leveno
Oct 1, 1982·Metabolism: Clinical and Experimental·W SternheimP J Speller
Jul 1, 1981·Kidney International·R A DeFronzoG Birkhead
Nov 15, 1981·American Journal of Obstetrics and Gynecology·D B CottonD A Goldstein
Dec 15, 1980·American Journal of Obstetrics and Gynecology·T L Gross, R J Sokol
Nov 1, 1993·Journal of the American Society of Nephrology : JASN·N S MorgunovD J Hirsch
Mar 1, 1957·American Journal of Obstetrics and Gynecology·C H HENDRICKS
Apr 15, 1964·American Journal of Obstetrics and Gynecology·A E SEEDSA E HELLEGERS

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Citations

Aug 5, 2003·The American Journal of Emergency Medicine·Yuh-Feng LinShih-Hua Lin
Aug 13, 1998·The New England Journal of Medicine·F J Gennari
Nov 26, 1999·Clinical Obstetrics and Gynecology·V L Katz, R M Farmer
Nov 9, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Desmond Bohn
May 17, 2012·Clinical Medicine : Journal of the Royal College of Physicians of London·Sharon Sturney, Jay Suntharalingam
Jul 4, 2015·Journal of Clinical Anesthesia·Hiroyuki KinoshitaYoshihiro Fujiwara
Mar 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S H Lin, Y F Lin
Aug 19, 2007·European Journal of Internal Medicine·Arsenio PompeoNicola Genovesi
Jun 27, 2006·Journal of Clinical Anesthesia·Daniel A Diedrich, Denise J Wedel
Mar 1, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jerry ChanNicholas M Fisk
Apr 22, 2008·Expert Opinion on Pharmacotherapy·K Y Ronald Kam, Ronald F Lamont
Dec 9, 2014·Case Reports in Medicine·Tina K ThethiPrathima Nagireddy
May 10, 2016·Expert Opinion on Drug Safety·Callum D LamontRonald F Lamont
Mar 9, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Tomoyuki ShimokazeYasufumi Itani
Feb 7, 2014·The Cochrane Database of Systematic Reviews·James P NeilsonTherese Dowswell
Dec 2, 2009·Korean Circulation Journal·Il-Suk SohnChong-Jin Kim
Apr 2, 2019·Current Pharmaceutical Design·Ronald F Lamont, Jan S Jørgensen
Jan 22, 2019·American Journal of Therapeutics·Karan N RamakrishnaHarvir Singh Gambhir
May 12, 2010·Basic & Clinical Pharmacology & Toxicology·Sa'ed H ZyoudSamah W Al-Jabi
Jun 5, 2015·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·E K Varadharaj, N Jampana
Nov 27, 2019·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Nikolaus PfistererJosef Finsterer
Jan 1, 2017·JA Clinical Reports·Daiki TakekawaKazuyoshi Hirota
Oct 6, 2005·Acta Paediatrica·Mamatha KambalapalliS Upadhyayula
Sep 20, 2016·The Journal of Obstetrics and Gynaecology Research·Masamitsu NakamuraAkihiko Sekizawa
Jan 2, 2020·Journal of Clinical Medicine·Alina G LiedtkePietro B Faré
Jul 1, 2020·The American Journal of Tropical Medicine and Hygiene·Saptarshi BhattacharyaVineet Surana

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