Rituximab and Acute Retinal Necrosis in a Patient with Scleromalacia and Rheumatoid Arthritis

Ocular Immunology and Inflammation
Sarah SchulerWolfgang Bernauer

Abstract

Rituximab is a widely used biologic agent, which has shown favourable results in the treatment of vasculitis. But immunosuppressive treatment also bears the risk of severe complications. A patient with rheumatoid arthritis, progressive scleromalacia, and acute retinal necrosis on therapy with rituximab is reported. For the first time, a correlation between rituximab and acute retinal necrosis in a patient with progressive rheumatoid scleromalacia is shown. Although rituximab is a promising biologic agent for the treatment of autoimmune diseases, it bears the risk of reactivation of viral infections, including the onset of acute retinal necrosis.

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Citations

Feb 18, 2016·Cutaneous and Ocular Toxicology·Neslihan SevimliYasar Dag
Feb 14, 2016·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Dec 21, 2016·Retinal Cases & Brief Reports·Sid A SchechetLisa S Schocket
Mar 13, 2019·Clinical & Experimental Ophthalmology·Xia Ni WuOren Tomkins-Netzer
Aug 25, 2018·Journal of Ophthalmic Inflammation and Infection·W BernauerL Borradori
Mar 11, 2020·BMJ Open Ophthalmology·Clara M Castillejo BecerraAlexa Simon Meara
Jan 11, 2021·Journal of the American Academy of Dermatology·Yuliya LytvynJensen Yeung
Jun 3, 2021·Journal of Clinical Medicine·Veronique PromelleJulie Gueudry
Aug 17, 2021·Journal of Ophthalmic Inflammation and Infection·Caleb C NgEmmett T Cunningham
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S JayashreeDipita Bhakta-Guha

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