Rituximab as an alternative for patients with severe systemic vasculitis refractory to conventional therapy: report of seven cases and literature review

Revista brasileira de reumatologia
Leonardo Sales da SilvaEutilia Andrade Medeiros Freire

Abstract

The greater understanding of pathophysiology and behavior of systemic vasculitis, together with the development of therapeutic regimens with increasingly better safety and efficacy profiles, dramatically changed the prognosis of patients diagnosed with these clinical entities. Recently, the use of rituximab in the treatment of patients with ANCA-associated vasculitis in randomized clinical trials showed an important alternative in selected cases, especially patients refractory or intolerant to standard therapy with cyclophosphamide and corticosteroids. This article presents the report of seven cases of systemic vasculitis successfully treated with rituximab.

References

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Jan 1, 2009·Case Reports in Medicine·Emmanuel RibeiroPatrick Mercié
Mar 31, 2010·Seminars in Hematology·George J Weiner
Jul 22, 2010·The New England Journal of Medicine·Rachel B JonesUNKNOWN European Vasculitis Study Group
Nov 5, 2010·International Journal of Rheumatology·Afsha KhanMichael J Green
Nov 29, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jing HughesWhitney W Woodmansee
Aug 2, 2013·The New England Journal of Medicine·Ulrich SpecksUNKNOWN RAVE-ITN Research Group
Oct 16, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Federico Alberici, David R W Jayne

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Citations

Sep 13, 2017·Clinical Reviews in Allergy & Immunology·Francesco MuratoreCarlo Salvarani

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