Rituximab-associated Vasculitis Flare: Incidence, Predictors, and Outcome.

The Journal of Rheumatology
Anne Claire DesboisDavid Saadoun

Abstract

To report the incidence, predictors, and outcome of rituximab (RTX)-associated autoimmune disease flare. We conducted a retrospective study in a tertiary referral center from 2005 to 2015. Disease flare was defined as the onset of a new organ involvement or worsening of autoimmune disease within 4 weeks following RTX. Among the 185 patients, we identified 7 disease flares (3.4%). All were due to type II mixed cryoglobulinemia vasculitis. Vasculitis flare occurred after a median time of 8 days (range 2-16) following RTX infusion and included acute kidney insufficiency (n = 7), purpura with cutaneous (n = 7), gastrointestinal (GI) tract involvement (n = 4), and myocarditis (n = 1). Patients with RTX-associated cryoglobulinemia vasculitis flare had these conditions more frequently: renal involvement (p = 0.0008), B cell lymphoproliferation (p = 0.015), higher level of cryoglobulin (2.1 vs 0.4 g/l, p = 0.0004), and lower level of C4 (0.02 vs 0.05, p = 0.023) compared to patients without flare after RTX (n = 43). Four patients (57%) died after a median time of 3.3 months. The 1-year survival rate was poorer in patients with vasculitis flare after RTX compared to their negative counterpart [43% (95% CI 18-100) vs 97% (95% CI 92-100),...Continue Reading

References

Nov 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B Hellerstedt, A Ahmed
Feb 14, 2012·International Journal of Rheumatic Diseases·Ashok KumarHemant Gopal
Nov 5, 2014·Nature·Richard T StraitFred D Finkelman
Jul 23, 2015·Seminars in Arthritis and Rheumatism·Paras KarmacharyaClifton O Bingham

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Citations

Sep 6, 2020·Internal and Emergency Medicine·Omer Karadag, Emine Duran
Oct 23, 2020·Modern Rheumatology Case Reports·Caterina VacchiMarco Sebastiani
Feb 18, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Elisabetta ChessaAlberto Cauli
Jul 1, 2021·The New England Journal of Medicine·Patrice Cacoub, David Saadoun
Jul 24, 2021·International Journal of Nephrology and Renovascular Disease·Ksymena LeśniakStanisław Niemczyk

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